7zls: Difference between revisions
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==co-crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 13== | |||
<StructureSection load='7zls' size='340' side='right'caption='[[7zls]], [[Resolution|resolution]] 1.92Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7zls]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZLS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZLS FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JH9:[4-[(2~{S})-3-[(4-fluoranyl-3-prop-2-enyl-phenyl)methylamino]-2-[2-(4-fluorophenyl)ethanoylamino]-3-oxidanylidene-propyl]phenyl]+dihydrogen+phosphate'>JH9</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zls OCA], [https://pdbe.org/7zls PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zls RCSB], [https://www.ebi.ac.uk/pdbsum/7zls PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zls ProSAT]</span></td></tr> | ||
[[Category: Ciulli | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/SOCS2_HUMAN SOCS2_HUMAN] SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Ciulli A]] | |||
[[Category: Makukhin N]] | |||
[[Category: Ramachandran S]] | |||
Revision as of 17:01, 26 April 2023
co-crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 13
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