1f2h: Difference between revisions

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[[Image:1f2h.gif|left|200px]]<br />

[[Image:1f2h.gif|left|200px]]<br /><applet load="1f2h" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1f2h" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1f2h" />

'''SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF THE TNFR1 ASSOCIATED PROTEIN, TRADD.'''<br />

==Overview==

TRADD is a multifunctional signaling adaptor protein that is recruited to, TNFR1 upon ligand binding. The C-terminal of TRADD comprises the "death, domain" that is responsible for association of TNFR1 and other death, domain-containing proteins such as FADD and RIP. The N-terminal domain, (N-TRADD) promotes the recruitment of TRAF2 to TNFR1 by binding to the, C-terminal of TRAF2, leading to the activation of JNK/AP1 and NF-kappa B., The solution structure of N-TRADD was determined, revealing a novel, protein fold. A combination of NMR, BIAcore, and mutagenesis experiments, was used to help identify the site of interaction of N-TRADD with C-TRAF2, providing a framework for future attempts to selectively inhibit the TNF, signaling pathways.

TRADD is a multifunctional signaling adaptor protein that is recruited to TNFR1 upon ligand binding. The C-terminal of TRADD comprises the "death domain" that is responsible for association of TNFR1 and other death domain-containing proteins such as FADD and RIP. The N-terminal domain (N-TRADD) promotes the recruitment of TRAF2 to TNFR1 by binding to the C-terminal of TRAF2, leading to the activation of JNK/AP1 and NF-kappa B. The solution structure of N-TRADD was determined, revealing a novel protein fold. A combination of NMR, BIAcore, and mutagenesis experiments was used to help identify the site of interaction of N-TRADD with C-TRAF2, providing a framework for future attempts to selectively inhibit the TNF signaling pathways.

==About this Structure==

1F2H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1F2H OCA].

1F2H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F2H OCA].

==Reference==

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[[Category: Single protein]]

[[Category: Hsu, H.]]

[[Category: Lin, L.L.]]

[[Category: Lin, L L.]]

[[Category: Malakian, K.]]

[[Category: McDonaugh, T.]]

[[Category: Telliez, J.B.]]

[[Category: Telliez, J B.]]

[[Category: Tsao, D.]]

[[Category: Xu, G.Y.]]

[[Category: Xu, G Y.]]

[[Category: tnfr-1 associated protein]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov~~ 12 16:48:~~31 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:34:03 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1f2h.gif|left|200px]]<br />
+[[Image:1f2h.gif|left|200px]]<br /><applet load="1f2h" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1f2h" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1f2h" />
 '''SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF THE TNFR1 ASSOCIATED PROTEIN, TRADD.'''<br />
 ==Overview==
-TRADD is a multifunctional signaling adaptor protein that is recruited to, TNFR1 upon ligand binding. The C-terminal of TRADD comprises the "death, domain" that is responsible for association of TNFR1 and other death, domain-containing proteins such as FADD and RIP. The N-terminal domain, (N-TRADD) promotes the recruitment of TRAF2 to TNFR1 by binding to the, C-terminal of TRAF2, leading to the activation of JNK/AP1 and NF-kappa B., The solution structure of N-TRADD was determined, revealing a novel, protein fold. A combination of NMR, BIAcore, and mutagenesis experiments, was used to help identify the site of interaction of N-TRADD with C-TRAF2, providing a framework for future attempts to selectively inhibit the TNF, signaling pathways.
+TRADD is a multifunctional signaling adaptor protein that is recruited to TNFR1 upon ligand binding. The C-terminal of TRADD comprises the "death domain" that is responsible for association of TNFR1 and other death domain-containing proteins such as FADD and RIP. The N-terminal domain (N-TRADD) promotes the recruitment of TRAF2 to TNFR1 by binding to the C-terminal of TRAF2, leading to the activation of JNK/AP1 and NF-kappa B. The solution structure of N-TRADD was determined, revealing a novel protein fold. A combination of NMR, BIAcore, and mutagenesis experiments was used to help identify the site of interaction of N-TRADD with C-TRAF2, providing a framework for future attempts to selectively inhibit the TNF signaling pathways.
 ==About this Structure==
-F2H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1F2H OCA].
+F2H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F2H OCA].
 ==Reference==
@@ Line 15: / Line 14: @@
 [[Category: Single protein]]
 [[Category: Hsu, H.]]
-[[Category: Lin, L.L.]]
+[[Category: Lin, L L.]]
 [[Category: Malakian, K.]]
 [[Category: McDonaugh, T.]]
-[[Category: Telliez, J.B.]]
+[[Category: Telliez, J B.]]
 [[Category: Tsao, D.]]
-[[Category: Xu, G.Y.]]
+[[Category: Xu, G Y.]]
 [[Category: tnfr-1 associated protein]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:48:31 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:34:03 2008''