7vad: Difference between revisions
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==== | ==Cryo-EM structure of human NTCP complexed with YN69202Fab== | ||
<StructureSection load='7vad' size='340' side='right'caption='[[7vad]]' scene=''> | <StructureSection load='7vad' size='340' side='right'caption='[[7vad]], [[Resolution|resolution]] 3.41Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7vad]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Ondatra_zibethicus Ondatra zibethicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VAD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VAD FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vad OCA], [https://pdbe.org/7vad PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vad RCSB], [https://www.ebi.ac.uk/pdbsum/7vad PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vad ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vad OCA], [https://pdbe.org/7vad PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vad RCSB], [https://www.ebi.ac.uk/pdbsum/7vad PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vad ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | |||
[[https://www.uniprot.org/uniprot/NTCP_HUMAN NTCP_HUMAN]] The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[[https://www.uniprot.org/uniprot/NTCP_HUMAN NTCP_HUMAN]] As a major transporter of conjugated bile salts from plasma into the hepatocyte, it has a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins. It exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. Able to transport taurocholate, cholate, and the non-bile acid estron sulfate (PubMed:14660639, PubMed:24867799).<ref>PMID:14660639</ref> <ref>PMID:24867799</ref> (Microbial infection) Acts as a receptor for hepatitis B virus.<ref>PMID:23150796</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Ondatra zibethicus]] | ||
[[Category: Asami J]] | |||
[[Category: Ohto U]] | |||
[[Category: Shimizu T]] | |||
Revision as of 06:27, 8 September 2022
Cryo-EM structure of human NTCP complexed with YN69202Fab
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