1f42: Difference between revisions

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[[Image:1f42.gif|left|200px]]<br />

[[Image:1f42.gif|left|200px]]<br /><applet load="1f42" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1f42" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1f42, resolution 2.5Å" />

'''THE P40 DOMAIN OF HUMAN INTERLEUKIN-12'''<br />

==Overview==

Human interleukin-12 (IL-12, p70) is an early pro-inflammatory cytokine, comprising two disulfide-linked subunits, p35 and p40. We solved the, crystal structures of monomeric human p40 at 2.5 A and the human p70, complex at 2.8 A resolution, which reveals that IL-12 is similar to class, 1 cytokine-receptor complexes. They also include the first description of, an N-terminal immunoglobulin-like domain, found on the p40 subunit., Several charged residues from p35 and p40 intercalate to form a unique, interlocking topography, shown by mutagenesis to be critical for p70, formation. A central arginine residue from p35 projects into a deep pocket, on p40, which may be an ideal target for a small molecule antagonist of, IL-12 formation.

Human interleukin-12 (IL-12, p70) is an early pro-inflammatory cytokine, comprising two disulfide-linked subunits, p35 and p40. We solved the crystal structures of monomeric human p40 at 2.5 A and the human p70 complex at 2.8 A resolution, which reveals that IL-12 is similar to class 1 cytokine-receptor complexes. They also include the first description of an N-terminal immunoglobulin-like domain, found on the p40 subunit. Several charged residues from p35 and p40 intercalate to form a unique interlocking topography, shown by mutagenesis to be critical for p70 formation. A central arginine residue from p35 projects into a deep pocket on p40, which may be an ideal target for a small molecule antagonist of IL-12 formation.

==Disease==

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==About this Structure==

1F42 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MNB as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1F42 OCA].

1F42 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MNB:'>MNB</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F42 OCA].

==Reference==

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[[Category: Homo sapiens]]

[[Category: Single protein]]

[[Category: Johnston, S.C.]]

[[Category: Johnston, S C.]]

[[Category: Somers, W.S.]]

[[Category: Somers, W S.]]

[[Category: Tang, J.]]

[[Category: Tobin, J.F.]]

[[Category: Tobin, J F.]]

[[Category: Yoon, C.]]

[[Category: MNB]]

[[Category: cytokine]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov~~ 12 16:48:~~59 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:34:35 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1f42.gif|left|200px]]<br />
+[[Image:1f42.gif|left|200px]]<br /><applet load="1f42" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1f42" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1f42, resolution 2.5&Aring;" />
 '''THE P40 DOMAIN OF HUMAN INTERLEUKIN-12'''<br />
 ==Overview==
-Human interleukin-12 (IL-12, p70) is an early pro-inflammatory cytokine, comprising two disulfide-linked subunits, p35 and p40. We solved the, crystal structures of monomeric human p40 at 2.5 A and the human p70, complex at 2.8 A resolution, which reveals that IL-12 is similar to class, 1 cytokine-receptor complexes. They also include the first description of, an N-terminal immunoglobulin-like domain, found on the p40 subunit., Several charged residues from p35 and p40 intercalate to form a unique, interlocking topography, shown by mutagenesis to be critical for p70, formation. A central arginine residue from p35 projects into a deep pocket, on p40, which may be an ideal target for a small molecule antagonist of, IL-12 formation.
+Human interleukin-12 (IL-12, p70) is an early pro-inflammatory cytokine, comprising two disulfide-linked subunits, p35 and p40. We solved the crystal structures of monomeric human p40 at 2.5 A and the human p70 complex at 2.8 A resolution, which reveals that IL-12 is similar to class 1 cytokine-receptor complexes. They also include the first description of an N-terminal immunoglobulin-like domain, found on the p40 subunit. Several charged residues from p35 and p40 intercalate to form a unique interlocking topography, shown by mutagenesis to be critical for p70 formation. A central arginine residue from p35 projects into a deep pocket on p40, which may be an ideal target for a small molecule antagonist of IL-12 formation.
 ==Disease==
@@ Line 11: / Line 10: @@
 ==About this Structure==
-F42 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MNB as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1F42 OCA].
+F42 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MNB:'>MNB</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F42 OCA].
 ==Reference==
@@ Line 17: / Line 16: @@
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
-[[Category: Johnston, S.C.]]
+[[Category: Johnston, S C.]]
-[[Category: Somers, W.S.]]
+[[Category: Somers, W S.]]
 [[Category: Tang, J.]]
-[[Category: Tobin, J.F.]]
+[[Category: Tobin, J F.]]
 [[Category: Yoon, C.]]
 [[Category: MNB]]
 [[Category: cytokine]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:48:59 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:34:35 2008''