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<StructureSection load='3ppm' size='340' side='right'caption='[[3ppm]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
<StructureSection load='3ppm' size='340' side='right'caption='[[3ppm]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ppm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PPM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PPM FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ppm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PPM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PPM FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1DO:1-DODECANOL'>1DO</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=F:FLUORIDE+ION'>F</scene>, <scene name='pdbligand=JG1:7-PHENYL-1-[5-(PYRIDIN-2-YL)-1,3,4-OXADIAZOL-2-YL]HEPTAN-1-ONE'>JG1</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.78&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wj1|2wj1]], [[2wj2|2wj2]], [[3k7f|3k7f]], [[3k83|3k83]], [[3k84|3k84]], [[3pr0|3pr0]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1DO:1-DODECANOL'>1DO</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=F:FLUORIDE+ION'>F</scene>, <scene name='pdbligand=JG1:7-PHENYL-1-[5-(PYRIDIN-2-YL)-1,3,4-OXADIAZOL-2-YL]HEPTAN-1-ONE'>JG1</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Faah, faah-1, Faah1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Fatty_acid_amide_hydrolase Fatty acid amide hydrolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.99 3.5.1.99] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ppm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ppm OCA], [https://pdbe.org/3ppm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ppm RCSB], [https://www.ebi.ac.uk/pdbsum/3ppm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ppm ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ppm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ppm OCA], [https://pdbe.org/3ppm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ppm RCSB], [https://www.ebi.ac.uk/pdbsum/3ppm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ppm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/FAAH1_RAT FAAH1_RAT]] Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity).  
[https://www.uniprot.org/uniprot/FAAH1_RAT FAAH1_RAT] Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Fatty acid amide hydrolase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Boger, D L]]
[[Category: Rattus norvegicus]]
[[Category: Han, G W]]
[[Category: Boger DL]]
[[Category: Mileni, M]]
[[Category: Han GW]]
[[Category: Stevens, R C]]
[[Category: Mileni M]]
[[Category: Endocannabinoid degradation]]
[[Category: Stevens RC]]
[[Category: Faah]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Membrane protein]]
[[Category: Oxadiazole]]
[[Category: Oxazole]]
[[Category: Protein-inhibitor complex]]
Retrieved from "https://proteopedia.org/3ppm"