1h7l: Difference between revisions

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[[Image:1h7l.jpg|left|200px]]
{{Seed}}
[[Image:1h7l.png|left|200px]]


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{{STRUCTURE_1h7l|  PDB=1h7l  |  SCENE=  }}  
{{STRUCTURE_1h7l|  PDB=1h7l  |  SCENE=  }}  


'''DTDP-MAGNESIUM COMPLEX OF SPSA FROM BACILLUS SUBTILIS'''
===DTDP-MAGNESIUM COMPLEX OF SPSA FROM BACILLUS SUBTILIS===




==Overview==
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The vast majority of glycosidic-bond synthesis in nature is performed by glycosyltransferases, which use activated glycosides as the sugar donor. Typically, the activated leaving group is a nucleoside phosphate, lipid phosphate or phosphate. The nucleotide-sugar-dependent glycosyltransferases fall into over 50 sequence-based families, with the largest and most widespread family of inverting transferases named family GT-2. Here, we present the three-dimensional crystal structure of SpsA, the first and currently the only structural representative from family GT-2, in complex with both Mn-dTDP and Mg-dTDP at a resolution of 2 A. These structures reveal how SpsA and related enzymes may display nucleotide plasticity and permit a comparison of the catalytic centre of this enzyme with those from related sequence families whose three-dimensional structures have recently been determined. Family GT-2 enzymes, together with enzymes from families 7, 13 and 43, appear to form a clan of related structures with identical catalytic apparatus and reaction mechanism.
The line below this paragraph, {{ABSTRACT_PUBMED_11733986}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11733986 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11733986}}


==About this Structure==
==About this Structure==
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[[Category: Glycosyltransferase]]
[[Category: Glycosyltransferase]]
[[Category: Transferase]]
[[Category: Transferase]]
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Revision as of 03:45, 1 July 2008

File:1h7l.png

Template:STRUCTURE 1h7l

DTDP-MAGNESIUM COMPLEX OF SPSA FROM BACILLUS SUBTILIS

Template:ABSTRACT PUBMED 11733986

About this Structure

1H7L is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Three-dimensional structures of the Mn and Mg dTDP complexes of the family GT-2 glycosyltransferase SpsA: a comparison with related NDP-sugar glycosyltransferases., Tarbouriech N, Charnock SJ, Davies GJ, J Mol Biol. 2001 Dec 7;314(4):655-61. PMID:11733986

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