1h7z: Difference between revisions

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[[Image:1h7z.jpg|left|200px]]
{{Seed}}
[[Image:1h7z.png|left|200px]]


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{{STRUCTURE_1h7z|  PDB=1h7z  |  SCENE=  }}  
{{STRUCTURE_1h7z|  PDB=1h7z  |  SCENE=  }}  


'''ADENOVIRUS AD3 FIBRE HEAD'''
===ADENOVIRUS AD3 FIBRE HEAD===




==Overview==
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Adenoviruses of serotype Ad3 (subgenus B) use a still-unknown host cell receptor for viral attachment, whereas viruses from all other known subgenera use the coxsackie and adenovirus receptor (CAR). The receptor binding domain (head) of the Ad3 fiber protein has been expressed in Escherichia coli inclusion bodies. After denaturation and renaturation using a rapid dilution method, crystals of trimeric head were obtained. The 1.6 A resolution X-ray structure shows a strict conservation of the beta-sheet scaffold of the protein very similar to the head structures of the CAR-binding serotypes Ad2, Ad5, and Ad12. The conformation of the loops is different, with the exception of the AB loop, which forms the center of the interface in the Ad12-CAR complex structure. The structure explains why a mutation in Ad5 of one residue in the AB loop to glutamic acid, as in Ad3, abrogates binding to CAR. It is possible that the Ad3 receptor binding site is nevertheless situated similar to the CAR binding site, although it cannot be excluded that other regions of the relatively hydrophobic head surface may be used.
The line below this paragraph, {{ABSTRACT_PUBMED_11437664}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11437664 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11437664}}


==About this Structure==
==About this Structure==
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[[Category: Fibre]]
[[Category: Fibre]]
[[Category: Receptor]]
[[Category: Receptor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:33:02 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:46:41 2008''

Revision as of 03:46, 1 July 2008

File:1h7z.png

Template:STRUCTURE 1h7z

ADENOVIRUS AD3 FIBRE HEAD

Template:ABSTRACT PUBMED 11437664

About this Structure

1H7Z is a Single protein structure of sequence from Human adenovirus 3. Full crystallographic information is available from OCA.

Reference

Structure of the fiber head of Ad3, a non-CAR-binding serotype of adenovirus., Durmort C, Stehlin C, Schoehn G, Mitraki A, Drouet E, Cusack S, Burmeister WP, Virology. 2001 Jul 5;285(2):302-12. PMID:11437664

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