3q3s: Difference between revisions

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<StructureSection load='3q3s' size='340' side='right'caption='[[3q3s]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='3q3s' size='340' side='right'caption='[[3q3s]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3q3s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q3S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q3S FirstGlance]. <br>
<table><tr><td colspan='2'>[[3q3s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q3S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q3S FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=O8B:2-(2-METHYLPHENOXY)-N-[2-(4-METHYLPHENYL)-2H-BENZOTRIAZOL-5-YL]ACETAMIDE'>O8B</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1u9n|1u9n]], [[3o8g|3o8g]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=O8B:2-(2-METHYLPHENOXY)-N-[2-(4-METHYLPHENYL)-2H-BENZOTRIAZOL-5-YL]ACETAMIDE'>O8B</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ethR, etaR, MT3970, Rv3855 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q3s OCA], [https://pdbe.org/3q3s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q3s RCSB], [https://www.ebi.ac.uk/pdbsum/3q3s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q3s ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q3s OCA], [https://pdbe.org/3q3s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q3s RCSB], [https://www.ebi.ac.uk/pdbsum/3q3s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q3s ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU]] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref>
[https://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref>  


==See Also==
==See Also==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lens, Z]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Villeret, V]]
[[Category: Lens Z]]
[[Category: Willand, N]]
[[Category: Villeret V]]
[[Category: Antitubercular agent]]
[[Category: Willand N]]
[[Category: Dna-binding protein]]
[[Category: Repressor protein]]
[[Category: Transcription repressor-inhibitor complex]]
[[Category: Tuberculosis]]

Latest revision as of 10:45, 21 February 2024

EthR from Mycobacterium tuberculosis in complex with compound BDM5683

3q3s, resolution 2.00Å

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