1h9v: Difference between revisions

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[[Image:1h9v.~~jpg~~|left|200px]]

[[Image:1h9v.png|left|200px]]

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~~'''~~HUMAN FC-GAMMA-RECEPTOR IIA (FCGRIIA), MONOCLINIC~~'''~~

===HUMAN FC-GAMMA-RECEPTOR IIA (FCGRIIA), MONOCLINIC===

~~==Overview==~~

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~~Once antigen is opsonised by IgG it is removed from the circulation by Fcgamma~~-~~receptor expressing cells. Fcgamma~~-~~receptors are type I transmembrane molecules that carry extracellular parts consisting of two or three immunoglobulin domains. Previously solved structures of Fc-receptors reveal that~~ the ~~N-terminal two Ig-like domains are arranged in a steep angle forming a heart-shaped structure. The crystal structure of~~ the ~~FcgammaRIII~~/~~hIgG1-Fc-fragment demonstrated that the Fc-fragment~~ is ~~recognised through loops of~~ the ~~C-terminal receptor domain of the FcgammaRIII~~. ~~As the overall structure of the FcRs and their Ig ligands are very similar we modelled the Ig complexes with FcgammaRI, FcgammaRII and FcepsilonRIalpha based on the FcgammaRIII/hIgG1~~-Fc-~~fragment structure. The obtained models are consistent with the observed biochemical data and may explain the observed specificity and affinities.~~

The line below this paragraph, {{ABSTRACT_PUBMED_11397093}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 11397093 is the PubMed ID number.

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==About this Structure==

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[[Category: Fcr]]

[[Category: Immunoglobulin]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 18~~:37:05 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 07:52:17 2008''

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-[[Image:1h9v.jpg|left|200px]]
+{{Seed}}
+[[Image:1h9v.png|left|200px]]
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 {{STRUCTURE_1h9v|  PDB=1h9v  |  SCENE=  }}
-'''HUMAN FC-GAMMA-RECEPTOR IIA (FCGRIIA), MONOCLINIC'''
+===HUMAN FC-GAMMA-RECEPTOR IIA (FCGRIIA), MONOCLINIC===
-==Overview==
+<!--
-Once antigen is opsonised by IgG it is removed from the circulation by Fcgamma-receptor expressing cells. Fcgamma-receptors are type I transmembrane molecules that carry extracellular parts consisting of two or three immunoglobulin domains. Previously solved structures of Fc-receptors reveal that the N-terminal two Ig-like domains are arranged in a steep angle forming a heart-shaped structure. The crystal structure of the FcgammaRIII/hIgG1-Fc-fragment demonstrated that the Fc-fragment is recognised through loops of the C-terminal receptor domain of the FcgammaRIII. As the overall structure of the FcRs and their Ig ligands are very similar we modelled the Ig complexes with FcgammaRI, FcgammaRII and FcepsilonRIalpha based on the FcgammaRIII/hIgG1-Fc-fragment structure. The obtained models are consistent with the observed biochemical data and may explain the observed specificity and affinities.
+The line below this paragraph, {{ABSTRACT_PUBMED_11397093}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11397093 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11397093}}
 ==About this Structure==
@@ Line 30: / Line 34: @@
 [[Category: Fcr]]
 [[Category: Immunoglobulin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 18:37:05 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 07:52:17 2008''