8czm: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 8czm is ~~ON HOLD until Paper Publication~~

==Crystal Structure of EcDsbA in a complex with 4-bromo-1H-pyrazole==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[8czm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CZM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CZM FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BYZ:4-BROMO-1H-PYRAZOLE'>BYZ</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8czm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8czm OCA], [https://pdbe.org/8czm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8czm RCSB], [https://www.ebi.ac.uk/pdbsum/8czm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8czm ProSAT]</span></td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/DSBA_ECOLI DSBA_ECOLI] Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. Required for pilus biogenesis. PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.<ref>PMID:1429594</ref> <ref>PMID:22267510</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Escherichia coli K-12]]

[[Category: Large Structures]]

[[Category: Ilyichova OV]]

[[Category: Taylor AJ]]

[[Category: Whitehouse RL]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8czm is ON HOLD  until Paper Publication
+==Crystal Structure of EcDsbA in a complex with 4-bromo-1H-pyrazole==
+<StructureSection load='8czm' size='340' side='right'caption='[[8czm]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8czm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CZM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CZM FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BYZ:4-BROMO-1H-PYRAZOLE'>BYZ</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8czm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8czm OCA], [https://pdbe.org/8czm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8czm RCSB], [https://www.ebi.ac.uk/pdbsum/8czm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8czm ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/DSBA_ECOLI DSBA_ECOLI] Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. Required for pilus biogenesis. PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.<ref>PMID:1429594</ref> <ref>PMID:22267510</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Escherichia coli K-12]]
+[[Category: Large Structures]]
+[[Category: Ilyichova OV]]
+[[Category: Taylor AJ]]
+[[Category: Whitehouse RL]]