8d10: Difference between revisions

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'''Unreleased structure'''


The entry 8d10 is ON HOLD  until Paper Publication
==Crystal Structure of EcDsbA in a complex with (1-methyl-1H-pyrazol-5-yl)methanamine==
 
<StructureSection load='8d10' size='340' side='right'caption='[[8d10]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
Authors: Whitehouse, R.L., Ilyichova, O.V., Taylor, A.J.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8d10]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D10 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D10 FirstGlance]. <br>
Description: Crystal Structure of EcDsbA in a complex with (1-methyl-1H-pyrazol-5-yl)methanamine
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=Q2I:1-(1-methyl-1H-pyrazol-5-yl)methanamine'>Q2I</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d10 OCA], [https://pdbe.org/8d10 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d10 RCSB], [https://www.ebi.ac.uk/pdbsum/8d10 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d10 ProSAT]</span></td></tr>
[[Category: Ilyichova, O.V]]
</table>
[[Category: Taylor, A.J]]
== Function ==
[[Category: Whitehouse, R.L]]
[https://www.uniprot.org/uniprot/DSBA_ECOLI DSBA_ECOLI] Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. Required for pilus biogenesis. PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.<ref>PMID:1429594</ref> <ref>PMID:22267510</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Ilyichova OV]]
[[Category: Taylor AJ]]
[[Category: Whitehouse RL]]