7s9v: Difference between revisions
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==== | ==DrmAB:ADP== | ||
<StructureSection load='7s9v' size='340' side='right'caption='[[7s9v]]' scene=''> | <StructureSection load='7s9v' size='340' side='right'caption='[[7s9v]], [[Resolution|resolution]] 3.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7s9v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Serratia Serratia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S9V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S9V FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s9v OCA], [https://pdbe.org/7s9v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s9v RCSB], [https://www.ebi.ac.uk/pdbsum/7s9v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s9v ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s9v OCA], [https://pdbe.org/7s9v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s9v RCSB], [https://www.ebi.ac.uk/pdbsum/7s9v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s9v ProSAT]</span></td></tr> | |||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
In the evolutionary arms race against phage, bacteria have assembled a diverse arsenal of antiviral immune strategies. While the recently discovered DISARM (Defense Island System Associated with Restriction-Modification) systems can provide protection against a wide range of phage, the molecular mechanisms that underpin broad antiviral targeting but avoiding autoimmunity remain enigmatic. Here, we report cryo-EM structures of the core DISARM complex, DrmAB, both alone and in complex with an unmethylated phage DNA mimetic. These structures reveal that DrmAB core complex is autoinhibited by a trigger loop (TL) within DrmA and binding to DNA substrates containing a 5' overhang dislodges the TL, initiating a long-range structural rearrangement for DrmAB activation. Together with structure-guided in vivo studies, our work provides insights into the mechanism of phage DNA recognition and specific activation of this widespread antiviral defense system. | |||
Structural basis for broad anti-phage immunity by DISARM.,Bravo JPK, Aparicio-Maldonado C, Nobrega FL, Brouns SJJ, Taylor DW Nat Commun. 2022 May 27;13(1):2987. doi: 10.1038/s41467-022-30673-1. PMID:35624106<ref>PMID:35624106</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 7s9v" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Serratia]] | ||
[[Category: Aparicio-Maldonado C]] | |||
[[Category: Bravo JPK]] | |||
[[Category: Brouns SJJ]] | |||
[[Category: Taylor DW]] | |||
