1fao: Difference between revisions
From Proteopedia
Jump to navigationJump to search
New page: left|200px<br /> <applet load="1fao" size="450" color="white" frame="true" align="right" spinBox="true" caption="1fao, resolution 1.80Å" /> '''STRUCTURE OF THE PL... |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1fao.gif|left|200px]]<br /> | [[Image:1fao.gif|left|200px]]<br /><applet load="1fao" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1fao" size=" | |||
caption="1fao, resolution 1.80Å" /> | caption="1fao, resolution 1.80Å" /> | ||
'''STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM DAPP1/PHISH IN COMPLEX WITH INOSITOL 1,3,4,5-TETRAKISPHOSPHATE'''<br /> | '''STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM DAPP1/PHISH IN COMPLEX WITH INOSITOL 1,3,4,5-TETRAKISPHOSPHATE'''<br /> | ||
==Overview== | ==Overview== | ||
Pleckstrin homology (PH) domains are protein modules of around 120 amino | Pleckstrin homology (PH) domains are protein modules of around 120 amino acids found in many proteins involved in cellular signaling. Certain PH domains drive signal-dependent membrane recruitment of their host proteins by binding strongly and specifically to lipid second messengers produced by agonist-stimulated phosphoinositide 3-kinases (PI 3-Ks). We describe X-ray crystal structures of two different PH domains bound to Ins(1,3,4,5)P4, the head group of the major PI 3-K product PtdIns(3,4,5)P3. One of these PH domains (from Grp1) is PtdIns(3,4,5)P3 specific, while the other (from DAPP1/PHISH) binds strongly to both PtdIns(3,4,5)P3 and its 5'-dephosphorylation product, PtdIns(3,4)P2. Comparison of the two structures provides an explanation for the distinct phosphoinositide specificities of the two PH domains and allows us to predict the 3-phosphoinositide selectivity of uncharacterized PH domains. | ||
==About this Structure== | ==About this Structure== | ||
1FAO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with 4IP as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 1FAO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=4IP:'>4IP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FAO OCA]. | ||
==Reference== | ==Reference== | ||
| Line 14: | Line 13: | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Ferguson, K | [[Category: Ferguson, K M.]] | ||
[[Category: Fournier, E.]] | [[Category: Fournier, E.]] | ||
[[Category: Isakoff, S | [[Category: Isakoff, S J.]] | ||
[[Category: Kavran, J | [[Category: Kavran, J M.]] | ||
[[Category: Lemmon, M | [[Category: Lemmon, M A.]] | ||
[[Category: Sankaran, V | [[Category: Sankaran, V G.]] | ||
[[Category: Skolnik, E | [[Category: Skolnik, E Y.]] | ||
[[Category: 4IP]] | [[Category: 4IP]] | ||
[[Category: 3-phosphoinositides]] | [[Category: 3-phosphoinositides]] | ||
| Line 27: | Line 26: | ||
[[Category: pleckstrin]] | [[Category: pleckstrin]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:36:40 2008'' | ||
