3rch: Difference between revisions

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<StructureSection load='3rch' size='340' side='right'caption='[[3rch]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='3rch' size='340' side='right'caption='[[3rch]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3rch]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RCH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RCH FirstGlance]. <br>
<table><tr><td colspan='2'>[[3rch]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RCH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RCH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3rbf|3rbf]], [[3rbl|3rbl]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AADC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Aromatic-L-amino-acid_decarboxylase Aromatic-L-amino-acid decarboxylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.28 4.1.1.28] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rch FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rch OCA], [https://pdbe.org/3rch PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rch RCSB], [https://www.ebi.ac.uk/pdbsum/3rch PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rch ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rch FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rch OCA], [https://pdbe.org/3rch PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rch RCSB], [https://www.ebi.ac.uk/pdbsum/3rch PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rch ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[https://www.uniprot.org/uniprot/DDC_HUMAN DDC_HUMAN]] Aromatic L-amino acid decarboxylase deficiency. The disease is caused by mutations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/DDC_HUMAN DDC_HUMAN] Aromatic L-amino acid decarboxylase deficiency. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/DDC_HUMAN DDC_HUMAN]] Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.  
[https://www.uniprot.org/uniprot/DDC_HUMAN DDC_HUMAN] Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Aromatic-L-amino-acid decarboxylase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Cellini, B]]
[[Category: Borri Voltattorni C]]
[[Category: Cutruzzola, F]]
[[Category: Cellini B]]
[[Category: Gianni, S]]
[[Category: Cutruzzola F]]
[[Category: Giardina, G]]
[[Category: Gianni S]]
[[Category: Montioli, R]]
[[Category: Giardina G]]
[[Category: Paiardini, A]]
[[Category: Montioli R]]
[[Category: Voltattorni, C Borri]]
[[Category: Paiardini A]]
[[Category: Aadc deficiency]]
[[Category: Apo enzyme]]
[[Category: Apo form]]
[[Category: Conformational change]]
[[Category: Ddc]]
[[Category: Decarboxylase]]
[[Category: Exposed]]
[[Category: Internal aldimine]]
[[Category: L-dopa]]
[[Category: Llp]]
[[Category: Lyase]]
[[Category: Open conformation]]
[[Category: Open dimer]]
[[Category: Parkinson]]
[[Category: Plp]]
[[Category: Shiff base]]
Retrieved from "https://proteopedia.org/3rch"