7wz9: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 7wz9 is ~~ON HOLD until 2024~~-02-17

==HSA-In agent complex==

~~Authors~~: ~~Zhang~~, Z.L., ~~Yang~~, F.

== Structural highlights ==

<table><tr><td colspan='2'>[[7wz9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WZ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WZ9 FirstGlance]. <br>

~~Description~~: ~~HSA-In agent complex~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7Q8:16-chloranyl-~{N},~{N}-dimethyl-15-thia-1$l^{4},12$l^{4},13-triaza-16$l^{4}-indatetracyclo[8.6.0.0^{2,7}.0^{12,16}]hexadeca-1,3,5,7,9,11,13-heptaen-14-amine'>7Q8</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wz9 OCA], [https://pdbe.org/7wz9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wz9 RCSB], [https://www.ebi.ac.uk/pdbsum/7wz9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wz9 ProSAT]</span></td></tr>

[[Category: ~~Zhang, Z.L~~]]

</table>

[[Category: Yang, F]]

== Disease ==

[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>

== Function ==

[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Yang F]]

[[Category: Zhang ZL]]

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-'''Unreleased structure'''
-The entry 7wz9 is ON HOLD  until 2024-02-17
+==HSA-In agent complex==
+<StructureSection load='7wz9' size='340' side='right'caption='[[7wz9]], [[Resolution|resolution]] 2.83&Aring;' scene=''>
-Authors: Zhang, Z.L., Yang, F.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7wz9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WZ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WZ9 FirstGlance]. <br>
-Description: HSA-In agent complex
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7Q8:16-chloranyl-~{N},~{N}-dimethyl-15-thia-1$l^{4},12$l^{4},13-triaza-16$l^{4}-indatetracyclo[8.6.0.0^{2,7}.0^{12,16}]hexadeca-1,3,5,7,9,11,13-heptaen-14-amine'>7Q8</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wz9 OCA], [https://pdbe.org/7wz9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wz9 RCSB], [https://www.ebi.ac.uk/pdbsum/7wz9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wz9 ProSAT]</span></td></tr>
-[[Category: Zhang, Z.L]]
+</table>
-[[Category: Yang, F]]
+== Disease ==
+[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Yang F]]
+[[Category: Zhang ZL]]