1hgc: Difference between revisions

Line 1:

[[Image:1hgc.~~jpg~~|left|200px]]

[[Image:1hgc.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN~~'''~~

===HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN===

~~==Overview==~~

<!--

The ~~origin of co-operativity in haemoglobin (Hb) resides in the reduced affinity of the T-state. T-state Hb crystals grown from polyethyleneglycol can be liganded without~~ the ~~molecule switching~~ to the ~~R high affinity state~~. ~~X-ray analysis of T-state alpha-oxy Hb and T-state met Hb has identified the structural basis for reduced affinity~~. ~~The nature of the chemical tension at the haem environment~~ is ~~different in~~ the ~~alpha and beta haems~~. ~~There are small but definite structural changes associated with ligation in the T~~-~~state: these prove to be mostly in the same direction as the larger changes that occur in the T~~-~~->R transition.~~

The line below this paragraph, {{ABSTRACT_PUBMED_1453464}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 1453464 is the PubMed ID number.

-->

==About this Structure==

Line 28:

Line 32:

[[Category: Liddington, R.]]

[[Category: Oxygen transport]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 18~~:49:25 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:09:15 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1hgc.jpg|left|200px]]
+{{Seed}}
+[[Image:1hgc.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1hgc|  PDB=1hgc  |  SCENE=  }}
-'''HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN'''
+===HIGH RESOLUTION CRYSTAL STRUCTURES AND COMPARISONS OF T STATE DEOXYHAEMOGLOBIN AND TWO LIGANDED T-STATE HAEMOGLOBINS: T(ALPHA-OXY)HAEMOGLOBIN AND T(MET)HAEMOGLOBIN===
-==Overview==
+<!--
-The origin of co-operativity in haemoglobin (Hb) resides in the reduced affinity of the T-state. T-state Hb crystals grown from polyethyleneglycol can be liganded without the molecule switching to the R high affinity state. X-ray analysis of T-state alpha-oxy Hb and T-state met Hb has identified the structural basis for reduced affinity. The nature of the chemical tension at the haem environment is different in the alpha and beta haems. There are small but definite structural changes associated with ligation in the T-state: these prove to be mostly in the same direction as the larger changes that occur in the T--&gt;R transition.
+The line below this paragraph, {{ABSTRACT_PUBMED_1453464}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 1453464 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_1453464}}
 ==About this Structure==
@@ Line 28: / Line 32: @@
 [[Category: Liddington, R.]]
 [[Category: Oxygen transport]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 18:49:25 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 08:09:15 2008''