3s5o: Difference between revisions

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<StructureSection load='3s5o' size='340' side='right'caption='[[3s5o]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
<StructureSection load='3s5o' size='340' side='right'caption='[[3s5o]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3s5o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S5O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S5O FirstGlance]. <br>
<table><tr><td colspan='2'>[[3s5o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S5O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S5O FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KPI:(2S)-2-AMINO-6-[(1-HYDROXY-1-OXO-PROPAN-2-YLIDENE)AMINO]HEXANOIC+ACID'>KPI</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=KPI:(2S)-2-AMINO-6-[(1-HYDROXY-1-OXO-PROPAN-2-YLIDENE)AMINO]HEXANOIC+ACID'>KPI</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3s5n|3s5n]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">C10orf65, DHDPSL, HOGA1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/4-hydroxy-2-oxoglutarate_aldolase 4-hydroxy-2-oxoglutarate aldolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.3.16 4.1.3.16] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s5o OCA], [https://pdbe.org/3s5o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s5o RCSB], [https://www.ebi.ac.uk/pdbsum/3s5o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s5o ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s5o OCA], [https://pdbe.org/3s5o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s5o RCSB], [https://www.ebi.ac.uk/pdbsum/3s5o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s5o ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[https://www.uniprot.org/uniprot/HOGA1_HUMAN HOGA1_HUMAN]] Primary hyperoxaluria type 3. The disease is caused by mutations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/HOGA1_HUMAN HOGA1_HUMAN] Primary hyperoxaluria type 3. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/HOGA1_HUMAN HOGA1_HUMAN]] Catalyzes the final step in the metabolic pathway of hydroxyproline.<ref>PMID:20797690</ref> <ref>PMID:21998747</ref>
[https://www.uniprot.org/uniprot/HOGA1_HUMAN HOGA1_HUMAN] Catalyzes the final step in the metabolic pathway of hydroxyproline.<ref>PMID:20797690</ref> <ref>PMID:21998747</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 4-hydroxy-2-oxoglutarate aldolase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lowther, W T]]
[[Category: Lowther WT]]
[[Category: Riedel, T J]]
[[Category: Riedel TJ]]
[[Category: Aldolase]]
[[Category: Beta barrel]]
[[Category: Hydroxyproline metabolism]]
[[Category: Lyase]]
[[Category: Schiff base]]
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