3s7m: Difference between revisions

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<StructureSection load='3s7m' size='340' side='right'caption='[[3s7m]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='3s7m' size='340' side='right'caption='[[3s7m]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3s7m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S7M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S7M FirstGlance]. <br>
<table><tr><td colspan='2'>[[3s7m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S7M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S7M FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=532:(5S)-2-AMINO-3-METHYL-5-[3-(PYRIDIN-3-YL)PHENYL]-5-(THIOPHEN-3-YL)-3,5-DIHYDRO-4H-IMIDAZOL-4-ONE'>532</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3s7l|3s7l]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=532:(5S)-2-AMINO-3-METHYL-5-[3-(PYRIDIN-3-YL)PHENYL]-5-(THIOPHEN-3-YL)-3,5-DIHYDRO-4H-IMIDAZOL-4-ONE'>532</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s7m OCA], [https://pdbe.org/3s7m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s7m RCSB], [https://www.ebi.ac.uk/pdbsum/3s7m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s7m ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s7m OCA], [https://pdbe.org/3s7m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s7m RCSB], [https://www.ebi.ac.uk/pdbsum/3s7m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s7m ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> 
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Memapsin 2]]
[[Category: Chopra R]]
[[Category: Chopra, R]]
[[Category: Olland A]]
[[Category: Olland, A]]
[[Category: Svenson K]]
[[Category: Svenson, K]]
[[Category: Aspartyl protease]]
[[Category: Disulfide bond]]
[[Category: Endoplasmic reticulum]]
[[Category: Endosome]]
[[Category: Glycoprotein]]
[[Category: Golgi apparatus]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Membrane]]
[[Category: Protease]]
[[Category: Transmembrane]]
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