1hk6: Difference between revisions

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[[Image:1hk6.jpg|left|200px]]
{{Seed}}
[[Image:1hk6.png|left|200px]]


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{{STRUCTURE_1hk6|  PDB=1hk6  |  SCENE=  }}  
{{STRUCTURE_1hk6|  PDB=1hk6  |  SCENE=  }}  


'''RAL BINDING DOMAIN FROM SEC5'''
===RAL BINDING DOMAIN FROM SEC5===




==Overview==
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The exocyst complex is involved in the final stages of exocytosis, when vesicles are targeted to the plasma membrane and dock. The regulation of exocytosis is vital for a number of processes, for example, cell polarity, embryogenesis, and neuronal growth formation. Regulation of the exocyst complex in mammals was recently shown to be dependent upon binding of the small G protein, Ral, to Sec5, a central component of the exocyst. This interaction is thought to be necessary for anchoring the exocyst to secretory vesicles. We have determined the structure of the Ral-binding domain of Sec5 and shown that it adopts a fold that has not been observed in a G protein effector before. This fold belongs to the immunoglobulin superfamily in a subclass known as IPT domains. We have mapped the Ral binding site on this domain and found that it overlaps with protein-protein interaction sites on other IPT domains but that it is completely different from the G protein-geranyl-geranyl interaction face of the Ig-like domain of the Rho guanine nucleotide dissociation inhibitor. This mapping, along with available site-directed mutagenesis data, allows us to predict how Ral and Sec5 may interact.
The line below this paragraph, {{ABSTRACT_PUBMED_12624092}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12624092 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12624092}}


==About this Structure==
==About this Structure==
1HK6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HK6 OCA].  
1HK6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HK6 OCA].  


==Reference==
==Reference==
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[[Category: Immunoglobulin fold]]
[[Category: Immunoglobulin fold]]
[[Category: Ipt ral sec5 exocyst,exocytosis,protein transport]]
[[Category: Ipt ral sec5 exocyst,exocytosis,protein transport]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:56:07 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:18:09 2008''

Revision as of 05:18, 1 July 2008

File:1hk6.png

Template:STRUCTURE 1hk6

RAL BINDING DOMAIN FROM SEC5

Template:ABSTRACT PUBMED 12624092

About this Structure

1HK6 is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

Structure of the GTPase-binding domain of Sec5 and elucidation of its Ral binding site., Mott HR, Nietlispach D, Hopkins LJ, Mirey G, Camonis JH, Owen D, J Biol Chem. 2003 May 9;278(19):17053-9. Epub 2003 Mar 6. PMID:12624092

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