1hk8: Difference between revisions

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[[Image:1hk8.~~gif~~|left|200px]]

[[Image:1hk8.png|left|200px]]

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~~'''~~STRUCTURAL BASIS FOR ALLOSTERIC SUBSTRATE SPECIFICITY REGULATION IN CLASS III RIBONUCLEOTIDE REDUCTASES: NRDD IN COMPLEX WITH DGTP~~'''~~

===STRUCTURAL BASIS FOR ALLOSTERIC SUBSTRATE SPECIFICITY REGULATION IN CLASS III RIBONUCLEOTIDE REDUCTASES: NRDD IN COMPLEX WITH DGTP===

~~==Overview==~~

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~~A Zn(Cys)(4) center has been found in the C-terminal region of the crystal structure of the anaerobic class III ribonucleotide reductase (RNR) from bacteriophage T4.~~ The ~~metal center is structurally related to the zinc ribbon motif and to rubredoxin and rubrerythrin. Mutant enzymes of the homologous RNR from Escherichia coli~~, ~~in which the coordinating cysteines~~, ~~conserved in almost all known class III RNR sequences, have been mutated into alanines, are shown to be inactive as~~ the ~~result of their inability~~ to ~~generate~~ the ~~catalytically essential glycyl radical~~. ~~The possible roles of~~ the ~~metal center are discussed in relationship to the currently proposed reaction mechanism for generation of the glycyl radical in class III RNRs~~.

The line below this paragraph, {{ABSTRACT_PUBMED_12655046}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12655046 is the PubMed ID number.

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==About this Structure==

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[[Category: Reductase]]

[[Category: Substrate specificity]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ 2 18:~~56:12~~ 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:18:10 2008''

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-[[Image:1hk8.gif|left|200px]]
+{{Seed}}
+[[Image:1hk8.png|left|200px]]
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 {{STRUCTURE_1hk8|  PDB=1hk8  |  SCENE=  }}
-'''STRUCTURAL BASIS FOR ALLOSTERIC SUBSTRATE SPECIFICITY REGULATION IN CLASS III RIBONUCLEOTIDE REDUCTASES: NRDD IN COMPLEX WITH DGTP'''
+===STRUCTURAL BASIS FOR ALLOSTERIC SUBSTRATE SPECIFICITY REGULATION IN CLASS III RIBONUCLEOTIDE REDUCTASES: NRDD IN COMPLEX WITH DGTP===
-==Overview==
+<!--
-A Zn(Cys)(4) center has been found in the C-terminal region of the crystal structure of the anaerobic class III ribonucleotide reductase (RNR) from bacteriophage T4. The metal center is structurally related to the zinc ribbon motif and to rubredoxin and rubrerythrin. Mutant enzymes of the homologous RNR from Escherichia coli, in which the coordinating cysteines, conserved in almost all known class III RNR sequences, have been mutated into alanines, are shown to be inactive as the result of their inability to generate the catalytically essential glycyl radical. The possible roles of the metal center are discussed in relationship to the currently proposed reaction mechanism for generation of the glycyl radical in class III RNRs.
+The line below this paragraph, {{ABSTRACT_PUBMED_12655046}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12655046 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12655046}}
 ==About this Structure==
@@ Line 32: / Line 36: @@
 [[Category: Reductase]]
 [[Category: Substrate specificity]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 18:56:12 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 08:18:10 2008''