7r7o: Difference between revisions
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==Structure of methyltransferase domain of Spb1 boudn to SAM== | ==Structure of methyltransferase domain of Spb1 boudn to SAM== | ||
<StructureSection load='7r7o' size='340' side='right'caption='[[7r7o]]' scene=''> | <StructureSection load='7r7o' size='340' side='right'caption='[[7r7o]], [[Resolution|resolution]] 1.58Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R7O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R7O FirstGlance]. <br> | <table><tr><td colspan='2'>[[7r7o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R7O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R7O FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r7o OCA], [https://pdbe.org/7r7o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r7o RCSB], [https://www.ebi.ac.uk/pdbsum/7r7o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r7o ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r7o OCA], [https://pdbe.org/7r7o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r7o RCSB], [https://www.ebi.ac.uk/pdbsum/7r7o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r7o ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/SPB1_YEAST SPB1_YEAST] Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Specifically methylates the guanosine in position 2922 of the 25S rRNA at the stage of 27S pre-rRNA maturation. Methylates also the uridine in position 2921 in the absence of methylation of this residue guided by snoRNA snR52 at the stage of 35S pre-rRNA maturation.[HAMAP-Rule:MF_03163]<ref>PMID:10556316</ref> <ref>PMID:14636587</ref> <ref>PMID:15546625</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Cruz | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Cruz VE]] | |||
[[Category: Erzberger JP]] | |||
[[Category: Peddada N]] | |||
[[Category: Sekulski K]] | |||
