3scz: Difference between revisions

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<StructureSection load='3scz' size='340' side='right'caption='[[3scz]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='3scz' size='340' side='right'caption='[[3scz]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3scz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SCZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SCZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[3scz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SCZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SCZ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HPA:HYPOXANTHINE'>HPA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3iom|3iom]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HPA:HYPOXANTHINE'>HPA</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">punA, deoD, Rv3307, MT3406, MTV016.06 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3scz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3scz OCA], [https://pdbe.org/3scz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3scz RCSB], [https://www.ebi.ac.uk/pdbsum/3scz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3scz ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3scz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3scz OCA], [https://pdbe.org/3scz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3scz RCSB], [https://www.ebi.ac.uk/pdbsum/3scz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3scz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/PUNA_MYCTU PUNA_MYCTU]] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine and inosine (By similarity).  
[https://www.uniprot.org/uniprot/PUNA_MYCTU PUNA_MYCTU] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine and inosine (By similarity).


==See Also==
==See Also==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Purine-nucleoside phosphorylase]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Azevedo, W F.de]]
[[Category: Basso LA]]
[[Category: Basso, L A]]
[[Category: Caceres RA]]
[[Category: Caceres, R A]]
[[Category: Ducati RG]]
[[Category: Ducati, R G]]
[[Category: Rosado LA]]
[[Category: Rosado, L A]]
[[Category: Santos DS]]
[[Category: Santos, D S]]
[[Category: Timmers LFSM]]
[[Category: Timmers, L F.S M]]
[[Category: De Azevedo Jr WF]]
[[Category: Hypoxanthine]]
[[Category: Inosine]]
[[Category: Purine nucleoside phosphorylase]]
[[Category: Transferase]]
[[Category: Tuberculosis]]

Latest revision as of 09:49, 1 March 2024

Combining crystallographic, thermodynamic, and molecular dynamics studies of Mycobacterium tuberculosis purine nucleoside phosphorylase

3scz, resolution 1.95Å

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