1hkt: Difference between revisions

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[[Image:1hkt.jpg|left|200px]]
{{Seed}}
[[Image:1hkt.png|left|200px]]


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{{STRUCTURE_1hkt|  PDB=1hkt  |  SCENE=  }}  
{{STRUCTURE_1hkt|  PDB=1hkt  |  SCENE=  }}  


'''SOLUTION STRUCTURE OF THE DNA-BINDING DOMAIN OF DROSOPHILA HEAT SHOCK TRANSCRIPTION FACTOR'''
===SOLUTION STRUCTURE OF THE DNA-BINDING DOMAIN OF DROSOPHILA HEAT SHOCK TRANSCRIPTION FACTOR===




==Overview==
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The solution structure of the DNA-binding domain of the Drosophila heat shock transcription factor, as determined by multidimensional multinuclear NMR, resembles that of the helix-turn-helix class of DNA-binding proteins. The domain comprises a four-stranded antiparallel beta-sheet, packed against a three-helix bundle. The second helix is significantly distorted and is separated from the third helix by an extended turn which is subject to conformational averaging on an intermediate time scale. Helix 3 forms a classical amphipathic helix with polar and charged residues exposed to the solvent. Upon titration with DNA, resonance shifts in the backbone and Asn and Gln side-chain amides indicate that helix 3 acts as the recognition helix of the heat shock transcription factor.
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{{ABSTRACT_PUBMED_7634100}}


==About this Structure==
==About this Structure==
1HKT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HKT OCA].  
1HKT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HKT OCA].  


==Reference==
==Reference==
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[[Category: Wu, C.]]
[[Category: Wu, C.]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:57:21 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:19:39 2008''

Revision as of 05:19, 1 July 2008

File:1hkt.png

Template:STRUCTURE 1hkt

SOLUTION STRUCTURE OF THE DNA-BINDING DOMAIN OF DROSOPHILA HEAT SHOCK TRANSCRIPTION FACTOR

Template:ABSTRACT PUBMED 7634100

About this Structure

1HKT is a Single protein structure of sequence from Drosophila melanogaster. Full experimental information is available from OCA.

Reference

Solution structure of the DNA-binding domain of Drosophila heat shock transcription factor., Vuister GW, Kim SJ, Orosz A, Marquardt J, Wu C, Bax A, Nat Struct Biol. 1994 Sep;1(9):605-14. PMID:7634100

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