1fkn: Difference between revisions

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[[Image:1fkn.gif|left|200px]]<br />

[[Image:1fkn.gif|left|200px]]<br /><applet load="1fkn" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1fkn" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1fkn, resolution 1.90Å" />

'''STRUCTURE OF BETA-SECRETASE COMPLEXED WITH INHIBITOR'''<br />

==Overview==

Memapsin 2 (beta-secretase) is a membrane-associated aspartic protease, involved in the production of beta-amyloid peptide in Alzheimer's disease, and is a major target for drug design. We determined the crystal structure, of the protease domain of human memapsin 2 complexed to an eight-residue, inhibitor at 1.9 angstrom resolution. The active site of memapsin 2 is, more open and less hydrophobic than that of other human aspartic, proteases. The subsite locations from S4 to S2' are well defined. A kink, of the inhibitor chain at P2' and the change of chain direction of P3' and, P4' may be mimicked to provide inhibitor selectivity.

Memapsin 2 (beta-secretase) is a membrane-associated aspartic protease involved in the production of beta-amyloid peptide in Alzheimer's disease and is a major target for drug design. We determined the crystal structure of the protease domain of human memapsin 2 complexed to an eight-residue inhibitor at 1.9 angstrom resolution. The active site of memapsin 2 is more open and less hydrophobic than that of other human aspartic proteases. The subsite locations from S4 to S2' are well defined. A kink of the inhibitor chain at P2' and the change of chain direction of P3' and P4' may be mimicked to provide inhibitor selectivity.

==About this Structure==

1FKN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1FKN with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb79_1.html Amyloid-beta Precursor Protein]]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1FKN OCA].

1FKN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1FKN with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb79_1.html Amyloid-beta Precursor Protein]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FKN OCA].

==Reference==

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[[Category: Terzyan, S.]]

[[Category: Wu, S.]]

[[Category: Zhang, X.C.]]

[[Category: Zhang, X C.]]

[[Category: alzheimer's disease]]

[[Category: aspartic protease]]

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[[Category: memapsin 2]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov~~ 12 16:54:~~23 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:39:41 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1fkn.gif|left|200px]]<br />
+[[Image:1fkn.gif|left|200px]]<br /><applet load="1fkn" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1fkn" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1fkn, resolution 1.90&Aring;" />
 '''STRUCTURE OF BETA-SECRETASE COMPLEXED WITH INHIBITOR'''<br />
 ==Overview==
-Memapsin 2 (beta-secretase) is a membrane-associated aspartic protease, involved in the production of beta-amyloid peptide in Alzheimer's disease, and is a major target for drug design. We determined the crystal structure, of the protease domain of human memapsin 2 complexed to an eight-residue, inhibitor at 1.9 angstrom resolution. The active site of memapsin 2 is, more open and less hydrophobic than that of other human aspartic, proteases. The subsite locations from S4 to S2' are well defined. A kink, of the inhibitor chain at P2' and the change of chain direction of P3' and, P4' may be mimicked to provide inhibitor selectivity.
+Memapsin 2 (beta-secretase) is a membrane-associated aspartic protease involved in the production of beta-amyloid peptide in Alzheimer's disease and is a major target for drug design. We determined the crystal structure of the protease domain of human memapsin 2 complexed to an eight-residue inhibitor at 1.9 angstrom resolution. The active site of memapsin 2 is more open and less hydrophobic than that of other human aspartic proteases. The subsite locations from S4 to S2' are well defined. A kink of the inhibitor chain at P2' and the change of chain direction of P3' and P4' may be mimicked to provide inhibitor selectivity.
 ==About this Structure==
-FKN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1FKN with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb79_1.html Amyloid-beta Precursor Protein]]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1FKN OCA].
+FKN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1FKN with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb79_1.html Amyloid-beta Precursor Protein]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FKN OCA].
 ==Reference==
@@ Line 22: / Line 21: @@
 [[Category: Terzyan, S.]]
 [[Category: Wu, S.]]
-[[Category: Zhang, X.C.]]
+[[Category: Zhang, X C.]]
 [[Category: alzheimer's disease]]
 [[Category: aspartic protease]]
@@ Line 29: / Line 28: @@
 [[Category: memapsin 2]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:54:23 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:39:41 2008''