7xw9: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Cryo-EM structure of the TRH-bound human TRHR-Gq complex== | |||
<StructureSection load='7xw9' size='340' side='right'caption='[[7xw9]], [[Resolution|resolution]] 2.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7xw9]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XW9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XW9 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xw9 OCA], [https://pdbe.org/7xw9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xw9 RCSB], [https://www.ebi.ac.uk/pdbsum/7xw9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xw9 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Disease == | ||
[[Category: | [https://www.uniprot.org/uniprot/TRFR_HUMAN TRFR_HUMAN] Resistance to thyrotropin-releasing hormone syndrome. The disease is caused by variants affecting the gene represented in this entry. | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/TRFR_HUMAN TRFR_HUMAN] Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.<ref>PMID:26735259</ref> <ref>PMID:9141550</ref> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: Shen | </StructureSection> | ||
[[Category: | [[Category: Bos taurus]] | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Rattus norvegicus]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Chen L]] | |||
[[Category: Dong Y]] | |||
[[Category: Guo J]] | |||
[[Category: Ji S]] | |||
[[Category: Mao C]] | |||
[[Category: Qin J]] | |||
[[Category: Shen D]] | |||
[[Category: Shen Q]] | |||
[[Category: Wang W]] | |||
[[Category: Zang S]] | |||
[[Category: Zhang H]] | |||
[[Category: Zhang Y]] | |||
Revision as of 08:59, 28 December 2022
Cryo-EM structure of the TRH-bound human TRHR-Gq complex
| ||||||||||||
