8cwj: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 8cwj is ~~ON HOLD until Paper Publication~~

==Fab arms of antibodies 4C12-B12 and CR3022 bound to pangolin receptor binding domain (pRBD)==

~~Authors~~: ~~Langley~~, D.B., ~~Christ~~, D.

== Structural highlights ==

<table><tr><td colspan='2'>[[8cwj]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Pangolin_coronavirus Pangolin coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CWJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CWJ FirstGlance]. <br>

~~Description~~: ~~Fab arms~~ of ~~antibodies 4C12~~-~~B12~~ and ~~CR3022 bound to pangolin receptor binding domain~~ (~~pRBD~~)

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cwj OCA], [https://pdbe.org/8cwj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cwj RCSB], [https://www.ebi.ac.uk/pdbsum/8cwj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cwj ProSAT]</span></td></tr>

[[Category: ~~Langley, D.B~~]]

</table>

[[Category: Christ, D]]

== Function ==

[https://www.uniprot.org/uniprot/A0A7D6TQ96_9BETC A0A7D6TQ96_9BETC] Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.[HAMAP-Rule:MF_04099] Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099] Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099]

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Pangolin coronavirus]]

[[Category: Christ D]]

[[Category: Langley DB]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8cwj is ON HOLD  until Paper Publication
+==Fab arms of antibodies 4C12-B12 and CR3022 bound to pangolin receptor binding domain (pRBD)==
+<StructureSection load='8cwj' size='340' side='right'caption='[[8cwj]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
-Authors: Langley, D.B., Christ, D.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8cwj]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Pangolin_coronavirus Pangolin coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CWJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CWJ FirstGlance]. <br>
-Description: Fab arms of antibodies 4C12-B12 and CR3022 bound to pangolin receptor binding domain (pRBD)
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cwj OCA], [https://pdbe.org/8cwj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cwj RCSB], [https://www.ebi.ac.uk/pdbsum/8cwj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cwj ProSAT]</span></td></tr>
-[[Category: Langley, D.B]]
+</table>
-[[Category: Christ, D]]
+== Function ==
+[https://www.uniprot.org/uniprot/A0A7D6TQ96_9BETC A0A7D6TQ96_9BETC] Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.[HAMAP-Rule:MF_04099]  Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]  Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099]
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Pangolin coronavirus]]
+[[Category: Christ D]]
+[[Category: Langley DB]]