7q1v: Difference between revisions

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<StructureSection load='7q1v' size='340' side='right'caption='[[7q1v]], [[Resolution|resolution]] 6.18&Aring;' scene=''>
<StructureSection load='7q1v' size='340' side='right'caption='[[7q1v]], [[Resolution|resolution]] 6.18&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7q1v]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q1V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q1V FirstGlance]. <br>
<table><tr><td colspan='2'>[[7q1v]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q1V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q1V FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q1v OCA], [https://pdbe.org/7q1v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q1v RCSB], [https://www.ebi.ac.uk/pdbsum/7q1v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q1v ProSAT]</span></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q1v OCA], [https://pdbe.org/7q1v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q1v RCSB], [https://www.ebi.ac.uk/pdbsum/7q1v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q1v ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[[https://www.uniprot.org/uniprot/O50335_ECOLX O50335_ECOLX]]
Bacterial conjugation is the fundamental process of unidirectional transfer of DNAs, often plasmid DNAs, from a donor cell to a recipient cell(1). It is the primary means by which antibiotic resistance genes spread among bacterial populations(2,3). In Gram-negative bacteria, conjugation is mediated by a large transport apparatus-the conjugative type IV secretion system (T4SS)-produced by the donor cell and embedded in both its outer and inner membranes. The T4SS also elaborates a long extracellular filament-the conjugative pilus-that is essential for DNA transfer(4,5). Here we present a high-resolution cryo-electron microscopy (cryo-EM) structure of a 2.8 megadalton T4SS complex composed of 92 polypeptides representing 8 of the 10 essential T4SS components involved in pilus biogenesis. We added the two remaining components to the structural model using co-evolution analysis of protein interfaces, to enable the reconstitution of the entire system including the pilus. This structure describes the exceptionally large protein-protein interaction network required to assemble the many components that constitute a T4SS and provides insights on the unique mechanism by which they elaborate pili.
 
Cryo-EM structure of a type IV secretion system.,Mace K, Vadakkepat AK, Redzej A, Lukoyanova N, Oomen C, Braun N, Ukleja M, Lu F, Costa TRD, Orlova EV, Baker D, Cong Q, Waksman G Nature. 2022 Jun 22. pii: 10.1038/s41586-022-04859-y. doi:, 10.1038/s41586-022-04859-y. PMID:35732732<ref>PMID:35732732</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7q1v" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lukoyanova, N]]
[[Category: Lukoyanova N]]
[[Category: Mace, K]]
[[Category: Mace K]]
[[Category: Vadakkepat, A K]]
[[Category: Vadakkepat AK]]
[[Category: Waksman, G]]
[[Category: Waksman G]]
[[Category: Arch]]
[[Category: Bacterial secretion]]
[[Category: Conjugation]]
[[Category: Imc]]
[[Category: Inner membrane]]
[[Category: Inner membrane complex]]
[[Category: Membrane protein]]
[[Category: Periplasmic]]
[[Category: Protein complex]]
[[Category: R388 plasmid]]
[[Category: Secretion]]
[[Category: Secretion system]]
[[Category: Stalk]]
[[Category: T4ss]]
[[Category: Trwg]]
[[Category: Trwi]]
[[Category: Trwj]]
[[Category: Trwk]]
[[Category: Trwm]]
[[Category: Type 4 secretion system]]
[[Category: Type iv secretion system]]
[[Category: Virb3]]
[[Category: Virb4]]
[[Category: Virb5]]
[[Category: Virb6]]
[[Category: Virb8]]

Latest revision as of 05:25, 8 September 2022

Arches protomer (trimer of TrwG/VirB8peri) structure from the fully-assembled R388 type IV secretion system determined by cryo-EM.

7q1v, resolution 6.18Å

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