3tfs: Difference between revisions
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<StructureSection load='3tfs' size='340' side='right'caption='[[3tfs]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='3tfs' size='340' side='right'caption='[[3tfs]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3tfs]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3tfs]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TFS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TFS FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FHA:2-DEOXY-5-O-[(S)-{(S)-FLUORO[(S)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]METHYL}(HYDROXY)PHOSPHORYL]ADENOSINE'>FHA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FHA:2-DEOXY-5-O-[(S)-{(S)-FLUORO[(S)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]METHYL}(HYDROXY)PHOSPHORYL]ADENOSINE'>FHA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tfs OCA], [https://pdbe.org/3tfs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tfs RCSB], [https://www.ebi.ac.uk/pdbsum/3tfs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tfs ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tfs OCA], [https://pdbe.org/3tfs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tfs RCSB], [https://www.ebi.ac.uk/pdbsum/3tfs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tfs ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref> | |||
==See Also== | |||
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Batra | [[Category: Batra VK]] | ||
[[Category: Beard | [[Category: Beard WA]] | ||
[[Category: Chamberlain | [[Category: Chamberlain BT]] | ||
[[Category: Goodman | [[Category: Goodman MF]] | ||
[[Category: Kadina | [[Category: Kadina AP]] | ||
[[Category: Kashemirov | [[Category: Kashemirov BA]] | ||
[[Category: McKenna | [[Category: McKenna CE]] | ||
[[Category: Shock | [[Category: Shock DD]] | ||
[[Category: Wilson | [[Category: Wilson SH]] | ||
Latest revision as of 13:27, 14 March 2024
Ternary complex structure of DNA polymerase beta with a gapped DNA substrate and a, b dAMP(CFH)PP in the active site: Stereoselective binding of (S) isomer
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