1hmp: Difference between revisions

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[[Image:1hmp.gif|left|200px]]
{{Seed}}
[[Image:1hmp.png|left|200px]]


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{{STRUCTURE_1hmp|  PDB=1hmp  |  SCENE=  }}  
{{STRUCTURE_1hmp|  PDB=1hmp  |  SCENE=  }}  


'''THE CRYSTAL STRUCTURE OF HUMAN HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE WITH BOUND GMP'''
===THE CRYSTAL STRUCTURE OF HUMAN HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE WITH BOUND GMP===




==Overview==
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The crystal structure of HGPRTase with bound GMP has been determined and refined to 2.5 A resolution. The enzyme has a core alpha/beta structure resembling the nucleotide-binding fold of dehydrogenases, and a second lobe composed of residues from the amino and carboxy termini. The GMP molecule binds in an anti conformation in a solvent-exposed cleft of the enzyme. Lys-165, which forms a hydrogen bond to O6 of GMP, appears to be critical for determining the specificity for guanine and hypoxanthine over adenine. The location of active site residues also provides evidence for a possible mechanism for general base-assisted HGPRTase catalysis. A rationalization of the effects on stability and activity of naturally occurring single amino acid mutations of HGPRTase is presented, including a discussion of several mutations at the active site that lead to Lesch-Nyhan syndrome.
The line below this paragraph, {{ABSTRACT_PUBMED_8044844}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_8044844}}


==About this Structure==
==About this Structure==
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[[Category: Scapin, G.]]
[[Category: Scapin, G.]]
[[Category: Xu, Y.]]
[[Category: Xu, Y.]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:01:14 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:24:24 2008''

Revision as of 05:24, 1 July 2008

File:1hmp.png

Template:STRUCTURE 1hmp

THE CRYSTAL STRUCTURE OF HUMAN HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE WITH BOUND GMP

Template:ABSTRACT PUBMED 8044844

About this Structure

1HMP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound GMP., Eads JC, Scapin G, Xu Y, Grubmeyer C, Sacchettini JC, Cell. 1994 Jul 29;78(2):325-34. PMID:8044844

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