Gasdermin

spinqualitylabelsall models Cryo-EM mouse gasdermin A3 pore complex with cardiolipin (PDB code 6cb8) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Gasdermin (GSDM) is the substrate of the inflammatory Caspase downstream from inflammasomes which activate caspase. Inflammasomes are supramolecular signalling assemblies activating the lytic process against exogenous pathogens. GSDM is required for cytokine release and pyroptosis, a lytic form of programmed cell death) . Pyropptosis is the regulated lytic cell death mediated by GSMD pore formation. GSDM D contains 2 domains: the N-terminal fragment which is pore-forming and the repressive C-terminal. The GSDM family contains 6 members in human. Disease GSDM is implicated in autoimmune diseases and certain cancers. Relevance Because of its potential as a driver of inflammation in septic shock and autoimmune diseases GSMD D is an attractive drug target, . Structural highlights This is a sample scene created with SAT to color by Group, and another to make a transparent representation of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

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Michal Harel