8d5q: Difference between revisions

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'''Unreleased structure'''


The entry 8d5q is ON HOLD  until Paper Publication
==TCR TG6 in complex with Ld-HF10==
<StructureSection load='8d5q' size='340' side='right'caption='[[8d5q]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8d5q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D5Q FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d5q OCA], [https://pdbe.org/8d5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d5q RCSB], [https://www.ebi.ac.uk/pdbsum/8d5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d5q ProSAT]</span></td></tr>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/HA1L_MOUSE HA1L_MOUSE]] Involved in the presentation of foreign antigens to the immune system.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Certain CD8 T cell responses are particularly effective at controlling infection, as exemplified by elite control of HIV in individuals harboring HLA-B57. To understand the structural features that contribute to CD8 T cell elite control, we focused on a strongly protective CD8 T cell response directed against a parasite-derived peptide (HF10) presented by an atypical MHC-I molecule, H-2Ld. This response exhibits a focused TCR repertoire dominated by Vbeta2, and a representative TCR (TG6) in complex with Ld-HF10 reveals an unusual structure in which both MHC and TCR contribute extensively to peptide specificity, along with a parallel footprint of TCR on its pMHC ligand. The parallel footprint is a common feature of Vbeta2-containing TCRs and correlates with an unusual Valpha-Vbeta interface, CDR loop conformations, and Vbeta2-specific germline contacts with peptides. Vbeta2 and Ld may represent "specialist" components for antigen recognition that allows for particularly strong and focused T cell responses.


Authors: Wang, Y., Dai, S.
Peptide Centric Vbeta Specific Germline Contacts Shape a Specialist T Cell Response.,Wang Y, Tsitsiklis A, Devoe S, Gao W, Chu HH, Zhang Y, Li W, Wong WK, Deane CM, Neau D, Slansky JE, Thomas PG, Robey EA, Dai S Front Immunol. 2022 Jul 29;13:847092. doi: 10.3389/fimmu.2022.847092. eCollection, 2022. PMID:35967379<ref>PMID:35967379</ref>


Description: TCR TG6 in complex with Ld-HF10
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Wang, Y]]
<div class="pdbe-citations 8d5q" style="background-color:#fffaf0;"></div>
[[Category: Dai, S]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Toxoplasma gondii]]
[[Category: Dai S]]
[[Category: Wang Y]]
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