1fnf: Difference between revisions

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[[Image:1fnf.gif|left|200px]]<br />

[[Image:1fnf.gif|left|200px]]<br /><applet load="1fnf" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1fnf" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1fnf, resolution 2.0Å" />

'''FRAGMENT OF HUMAN FIBRONECTIN ENCOMPASSING TYPE-III REPEATS 7 THROUGH 10'''<br />

==Overview==

We have determined the 2.0 A crystal structure of a fragment of human, fibronectin encompassing the seventh through the RGD-containing tenth type, III repeats (FN7-10). The structure reveals an extended rod-like molecule, with a long axis of approximately 140 A and highly variable relationships, between adjacent domains. An unusually small rotation between domains 9, and 10 creates a distinctive binding site, in which the RGD loop from, domain 10 and the "synergy" region from domain 9 are on the same face of, FN7-10 and thus easily accessible to a single integrin molecule. The, cell-binding RGD loop is well-ordered in this structure and extends, approximately 10 A away from the FN7-10 core.

We have determined the 2.0 A crystal structure of a fragment of human fibronectin encompassing the seventh through the RGD-containing tenth type III repeats (FN7-10). The structure reveals an extended rod-like molecule with a long axis of approximately 140 A and highly variable relationships between adjacent domains. An unusually small rotation between domains 9 and 10 creates a distinctive binding site, in which the RGD loop from domain 10 and the "synergy" region from domain 9 are on the same face of FN7-10 and thus easily accessible to a single integrin molecule. The cell-binding RGD loop is well-ordered in this structure and extends approximately 10 A away from the FN7-10 core.

==Disease==

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==About this Structure==

1FNF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1FNF OCA].

1FNF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNF OCA].

==Reference==

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[[Category: Single protein]]

[[Category: Aukhil, I.]]

[[Category: Erickson, H.P.]]

[[Category: Erickson, H P.]]

[[Category: Leahy, D.J.]]

[[Category: Leahy, D J.]]

[[Category: extracellular matrix]]

[[Category: rgd]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov~~ 12 16:55:~~25 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:40:32 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1fnf.gif|left|200px]]<br />
+[[Image:1fnf.gif|left|200px]]<br /><applet load="1fnf" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1fnf" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1fnf, resolution 2.0&Aring;" />
 '''FRAGMENT OF HUMAN FIBRONECTIN ENCOMPASSING TYPE-III REPEATS 7 THROUGH 10'''<br />
 ==Overview==
-We have determined the 2.0 A crystal structure of a fragment of human, fibronectin encompassing the seventh through the RGD-containing tenth type, III repeats (FN7-10). The structure reveals an extended rod-like molecule, with a long axis of approximately 140 A and highly variable relationships, between adjacent domains. An unusually small rotation between domains 9, and 10 creates a distinctive binding site, in which the RGD loop from, domain 10 and the "synergy" region from domain 9 are on the same face of, FN7-10 and thus easily accessible to a single integrin molecule. The, cell-binding RGD loop is well-ordered in this structure and extends, approximately 10 A away from the FN7-10 core.
+We have determined the 2.0 A crystal structure of a fragment of human fibronectin encompassing the seventh through the RGD-containing tenth type III repeats (FN7-10). The structure reveals an extended rod-like molecule with a long axis of approximately 140 A and highly variable relationships between adjacent domains. An unusually small rotation between domains 9 and 10 creates a distinctive binding site, in which the RGD loop from domain 10 and the "synergy" region from domain 9 are on the same face of FN7-10 and thus easily accessible to a single integrin molecule. The cell-binding RGD loop is well-ordered in this structure and extends approximately 10 A away from the FN7-10 core.
 ==Disease==
@@ Line 11: / Line 10: @@
 ==About this Structure==
-FNF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1FNF OCA].
+FNF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNF OCA].
 ==Reference==
@@ Line 18: / Line 17: @@
 [[Category: Single protein]]
 [[Category: Aukhil, I.]]
-[[Category: Erickson, H.P.]]
+[[Category: Erickson, H P.]]
-[[Category: Leahy, D.J.]]
+[[Category: Leahy, D J.]]
 [[Category: extracellular matrix]]
 [[Category: rgd]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:55:25 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:40:32 2008''