7owb: Difference between revisions
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==Chimeric carminomycin-4-O-methyltransferase (DnrK) with a region from 10-hydroxylase CalMB== | ==Chimeric carminomycin-4-O-methyltransferase (DnrK) with a region from 10-hydroxylase CalMB== | ||
<StructureSection load='7owb' size='340' side='right'caption='[[7owb]]' scene=''> | <StructureSection load='7owb' size='340' side='right'caption='[[7owb]], [[Resolution|resolution]] 2.45Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OWB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OWB FirstGlance]. <br> | <table><tr><td colspan='2'>[[7owb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_peucetius Streptomyces peucetius] and [https://en.wikipedia.org/wiki/Streptomyces_sp._ZEA17I Streptomyces sp. ZEA17I]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OWB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OWB FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7owb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7owb OCA], [https://pdbe.org/7owb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7owb RCSB], [https://www.ebi.ac.uk/pdbsum/7owb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7owb ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3VL:METHYL+(1R,2R,4S)-2-ETHYL-2,5,7-TRIHYDROXY-6,11-DIOXO-4-{[2,3,6-TRIDEOXY-3-(DIMETHYLAMINO)-ALPHA-L-LYXO-HEXOPYRANOSYL]OXY}-1,2,3,4,6,11-HEXAHYDROTETRACENE-1-CARBOXYLATE'>3VL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7owb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7owb OCA], [https://pdbe.org/7owb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7owb RCSB], [https://www.ebi.ac.uk/pdbsum/7owb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7owb ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/A0A2V2Q0Q4_9ACTN A0A2V2Q0Q4_9ACTN]] [[https://www.uniprot.org/uniprot/DNRK_STRPE DNRK_STRPE]] Involved in the biosynthesis of the anthracyclines carminomycin and daunorubicin (daunomycin) which are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers. In vivo, catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the 4-O-position of carminomycin to form daunorubicin. In vitro, it also methylates the anthracyclines rhodomycin D (10-carbomethoxy-13-deoxycarminomycin) and 13-deoxy-carminomycin at the 4-hydroxyl position. It is quite specific with respect to the length of the carbohydrate chain at the C7 position, but it can accept substrates with bulky substituent at C10 position.<ref>PMID:15273252</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Streptomyces peucetius]] | |||
[[Category: Streptomyces sp. ZEA17I]] | |||
[[Category: Dinis P]] | [[Category: Dinis P]] | ||
[[Category: MetsaKetela M]] | [[Category: MetsaKetela M]] | ||
Revision as of 05:41, 8 September 2022
Chimeric carminomycin-4-O-methyltransferase (DnrK) with a region from 10-hydroxylase CalMB
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