1hoy: Difference between revisions

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[[Image:1hoy.gif|left|200px]]
{{Seed}}
[[Image:1hoy.png|left|200px]]


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{{STRUCTURE_1hoy|  PDB=1hoy  |  SCENE=  }}  
{{STRUCTURE_1hoy|  PDB=1hoy  |  SCENE=  }}  


'''NMR STRUCTURE OF THE COMPLEX BETWEEN A-BUNGAROTOXIN AND A MIMOTOPE OF THE NICOTINIC ACETILCHOLINE RECEPTOR'''
===NMR STRUCTURE OF THE COMPLEX BETWEEN A-BUNGAROTOXIN AND A MIMOTOPE OF THE NICOTINIC ACETILCHOLINE RECEPTOR===




==Overview==
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A combinatorial library approach was used to produce synthetic peptides mimicking the snake neurotoxin binding site of nicotinic receptors. Among the sequences, which inhibited binding of alpha-bungarotoxin to muscle and neuronal nicotinic receptors, HRYYESSLPWYPD, a 14-amino acid peptide with considerably higher toxin-binding affinity than the other synthesized peptides, was selected, and the structure of its complex with the toxin was analyzed by NMR. Comparison of the solution structure of the free toxin and its complex with this peptide indicated that complex formation induced extensive conformational rearrangements mainly at finger II and the carboxy terminus of the protein. The peptidyl residues P10 and Y4 seemed to be critical for peptide folding and complex stability, respectively. The latter residue of the peptide strongly interacted with the protein by entering a small pocket delimited by D30, C33, S34, R36, and V39 toxin side chains.
The line below this paragraph, {{ABSTRACT_PUBMED_11814338}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11814338 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11814338}}


==About this Structure==
==About this Structure==
1HOY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bungarus_multicinctus Bungarus multicinctus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HOY OCA].  
1HOY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bungarus_multicinctus Bungarus multicinctus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HOY OCA].  


==Reference==
==Reference==
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[[Category: Spiga, O.]]
[[Category: Spiga, O.]]
[[Category: Alpha-bungarotoxin,protein-peptide complex,acchor mimotope,toxin,beta-strand]]
[[Category: Alpha-bungarotoxin,protein-peptide complex,acchor mimotope,toxin,beta-strand]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:04:40 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:29:10 2008''
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