3uc8: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3uc8]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UC8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UC8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3uc8]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UC8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UC8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.33&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3uc7|3uc7]], [[2ll5|2ll5]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uc8 OCA], [https://pdbe.org/3uc8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uc8 RCSB], [https://www.ebi.ac.uk/pdbsum/3uc8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uc8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uc8 OCA], [https://pdbe.org/3uc8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uc8 RCSB], [https://www.ebi.ac.uk/pdbsum/3uc8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uc8 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
To provide high-resolution X-ray crystallographic structures of a peptide with the Trp-cage fold, we prepared a cyclized version of this motif. Cyclized Trp-cage is remarkably stable and afforded two crystal forms suitable for X-ray diffraction. The resulting higher resolution crystal structures validate the prior NMR models and provide explanations for experimental observations that could not be rationalized by NMR structural data, including the structural basis for the increase in fold stability associated with motif cyclization and the manner in which a polar serine side chain is accommodated in the hydrophobic interior. A hexameric oligomer of the cyclic peptide is found in both crystal forms and indicates that under appropriate conditions, this minimized system may also serve as a model for protein-protein interactions.
Crystal and NMR structures of a Trp-cage mini-protein benchmark for computational fold prediction.,Scian M, Lin JC, Le Trong I, Makhatadze GI, Stenkamp RE, Andersen NH Proc Natl Acad Sci U S A. 2012 Jul 16. PMID:22802678<ref>PMID:22802678</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3uc8" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Andersen, N H]]
[[Category: Andersen NH]]
[[Category: Scian, M]]
[[Category: Le Trong I]]
[[Category: Stenkamp, R E]]
[[Category: Scian M]]
[[Category: Trong, I Le]]
[[Category: Stenkamp RE]]
[[Category: Cyclic peptide]]
[[Category: De novo protein]]
[[Category: Miniprotein]]
[[Category: Multimer]]
[[Category: Protein-protein interaction]]
[[Category: Trp-cage]]

Revision as of 13:54, 14 March 2024

Trp-cage cyclo-TC1 - tetragonal crystal form

3uc8, resolution 1.33Å

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