7y14: Difference between revisions
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==Cryo-EM structure of MrgD-Gi complex with beta-alanine (local)== | ==Cryo-EM structure of MrgD-Gi complex with beta-alanine (local)== | ||
<StructureSection load='7y14' size='340' side='right'caption='[[7y14]]' scene=''> | <StructureSection load='7y14' size='340' side='right'caption='[[7y14]], [[Resolution|resolution]] 3.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y14 FirstGlance]. <br> | <table><tr><td colspan='2'>[[7y14]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y14 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y14 OCA], [https://pdbe.org/7y14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y14 RCSB], [https://www.ebi.ac.uk/pdbsum/7y14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y14 ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BAL:BETA-ALANINE'>BAL</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y14 OCA], [https://pdbe.org/7y14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y14 RCSB], [https://www.ebi.ac.uk/pdbsum/7y14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y14 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/MRGRD_HUMAN MRGRD_HUMAN]] May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i).[[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX]] Electron-transport protein of unknown function. | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Escherichia coli]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Iida M]] | [[Category: Iida M]] | ||
Revision as of 05:04, 8 September 2022
Cryo-EM structure of MrgD-Gi complex with beta-alanine (local)
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