1hqd: Difference between revisions

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[[Image:1hqd.gif|left|200px]]
{{Seed}}
[[Image:1hqd.png|left|200px]]


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{{STRUCTURE_1hqd|  PDB=1hqd  |  SCENE=  }}  
{{STRUCTURE_1hqd|  PDB=1hqd  |  SCENE=  }}  


'''PSEUDOMONAS CEPACIA LIPASE COMPLEXED WITH TRANSITION STATE ANALOGUE OF 1-PHENOXY-2-ACETOXY BUTANE'''
===PSEUDOMONAS CEPACIA LIPASE COMPLEXED WITH TRANSITION STATE ANALOGUE OF 1-PHENOXY-2-ACETOXY BUTANE===




==Overview==
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In a series of four racemic phenoxyalkyl-alkyl carbinols, 1-phenoxy-2-hydroxybutane (1) is enantioselectively acetylated by Burkholderia cepacia (formerly Pseudomonas cepacia) lipase with an E value &gt; or = 200, whereas for the other three racemates E was found to be &lt; or = 4. To explain the high preference of B. cepacia lipase for (R)-(+)-1, a precursor of its transition state analogue with a tetrahedral P-atom, (R(P),S(P))-O-(2R)-(1-phenoxybut-2-yl)methylphosphonic acid chloride was prepared and crystallized in complex with B. cepacia lipase. The X-ray structure of the complex was determined, allowing to compare the conformation of the inhibitor with results of molecular modelling.
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{{ABSTRACT_PUBMED_11453990}}


==About this Structure==
==About this Structure==
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[[Category: Pseudomonas cepacia lipase]]
[[Category: Pseudomonas cepacia lipase]]
[[Category: Racemic sec alcohol]]
[[Category: Racemic sec alcohol]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:32:11 2008''

Revision as of 05:32, 1 July 2008

File:1hqd.png

Template:STRUCTURE 1hqd

PSEUDOMONAS CEPACIA LIPASE COMPLEXED WITH TRANSITION STATE ANALOGUE OF 1-PHENOXY-2-ACETOXY BUTANE

Template:ABSTRACT PUBMED 11453990

About this Structure

1HQD is a Single protein structure of sequence from Burkholderia cepacia. Full crystallographic information is available from OCA.

Reference

Complex of Burkholderia cepacia lipase with transition state analogue of 1-phenoxy-2-acetoxybutane: biocatalytic, structural and modelling study., Luic M, Tomic S, Lescic I, Ljubovic E, Sepac D, Sunjic V, Vitale L, Saenger W, Kojic-Prodic B, Eur J Biochem. 2001 Jul;268(14):3964-73. PMID:11453990

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