3uk3: Difference between revisions

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<StructureSection load='3uk3' size='340' side='right'caption='[[3uk3]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='3uk3' size='340' side='right'caption='[[3uk3]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3uk3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UK3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UK3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3uk3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UK3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UK3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ZNF217, ZABC1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uk3 OCA], [https://pdbe.org/3uk3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uk3 RCSB], [https://www.ebi.ac.uk/pdbsum/3uk3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uk3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uk3 OCA], [https://pdbe.org/3uk3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uk3 RCSB], [https://www.ebi.ac.uk/pdbsum/3uk3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uk3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/ZN217_HUMAN ZN217_HUMAN]] Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'.<ref>PMID:16203743</ref> <ref>PMID:17259635</ref> <ref>PMID:18625718</ref> <ref>PMID:16940172</ref>
[https://www.uniprot.org/uniprot/ZN217_HUMAN ZN217_HUMAN] Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'.<ref>PMID:16203743</ref> <ref>PMID:17259635</ref> <ref>PMID:18625718</ref> <ref>PMID:16940172</ref>  
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Guss, J M]]
[[Category: Guss JM]]
[[Category: Jacques, D A]]
[[Category: Jacques DA]]
[[Category: Mackay, J P]]
[[Category: Mackay JP]]
[[Category: Vandevenne, M S]]
[[Category: Vandevenne MS]]
[[Category: Dna binding]]
[[Category: Dna-metal binding protein complex]]
[[Category: Transcription factor]]
[[Category: Zinc finger]]

Latest revision as of 08:38, 20 March 2024

Crystal structure of ZNF217 bound to DNA

3uk3, resolution 2.10Å

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