Stringent starvation protein: Difference between revisions
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'''Stringent starvation protein''' A (SspA) is an RNA polymerase-associated protein involved in nucleotide metabolism acid tolerance and virulence of bacteria<ref>PMID:32785630</ref>. | '''Stringent starvation protein''' A (SspA) is an RNA polymerase-associated protein involved in nucleotide metabolism acid tolerance and virulence of bacteria<ref>PMID:32785630</ref>. | ||
In ''Francisella'' virulence, a set of regulators are essensial for its activation. These regulators include the | In ''Francisella'' virulence, a set of regulators are essensial for its activation. These regulators include the heterodimer of SspA, macrophage growth locus A (MglA) and pathogenicity island gene regulator (PigR). The guanosine-tetraphosphate (ppGpp) is also involved in coordinating the virulence. | ||
== Relevance == | == Relevance == | ||
Tularemia caused by the pathogen ''Francisella tularensis'' may be treated by inhibitors of SspA-MglA regulators. | |||
== Structural highlights == | == Structural highlights == | ||
The 3D structure of the complex of SspA and MglA shows a heterodimer with favourable interactions between the two molecules<ref>PMID:18864445</ref>. The ppGpp molecule binds to the open face of the SspA-MglA heterodimer interacting with both molecules | |||
== 3D structures of stringent starvation protein == | |||
[[Stringent starvation protein 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | |||
