Stringent starvation protein: Difference between revisions
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== Function == | == Function == | ||
'''Stringent starvation protein''' A (SspA) is an RNA polymerase-associated protein involved in nucleotide metabolism acid tolerance and virulence of bacteria<ref>PMID:32785630</ref>. | '''Stringent starvation protein''' A (SspA) is an RNA polymerase-associated protein involved in nucleotide metabolism, acid tolerance and virulence of bacteria<ref>PMID:32785630</ref>. | ||
In ''Francisella'' virulence, a set of regulators are essensial for its activation. These regulators include the heterodimer of SspA, macrophage growth locus A (MglA) and pathogenicity island gene regulator (PigR). The guanosine-tetraphosphate (ppGpp) is also involved in coordinating the virulence. '''Stringent starvation protein B''' (SspB) binds to residues in the tag of tmRNA proteins marking them for degradation <ref>PMID:11535833</ref>. | In ''Francisella'' virulence, a set of regulators are essensial for its activation. These regulators include the heterodimer of SspA, macrophage growth locus A (MglA) and pathogenicity island gene regulator (PigR). The guanosine-tetraphosphate (ppGpp) is also involved in coordinating the virulence. '''Stringent starvation protein B''' (SspB) binds to residues in the tag of tmRNA proteins marking them for degradation <ref>PMID:11535833</ref>. | ||
