7n6f: Difference between revisions
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==Co-complex CYP46A1 with compound 3f== | ==Co-complex CYP46A1 with compound 3f== | ||
<StructureSection load='7n6f' size='340' side='right'caption='[[7n6f]]' scene=''> | <StructureSection load='7n6f' size='340' side='right'caption='[[7n6f]], [[Resolution|resolution]] 1.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7N6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7N6F FirstGlance]. <br> | <table><tr><td colspan='2'>[[7n6f]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7N6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7N6F FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n6f OCA], [https://pdbe.org/7n6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n6f RCSB], [https://www.ebi.ac.uk/pdbsum/7n6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n6f ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0I1:(3-fluoroazetidin-1-yl){1-[4-(4-fluorophenyl)pyrimidin-5-yl]piperidin-4-yl}methanone'>0I1</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cholesterol_24-hydroxylase Cholesterol 24-hydroxylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.25 1.14.14.25] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n6f OCA], [https://pdbe.org/7n6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n6f RCSB], [https://www.ebi.ac.uk/pdbsum/7n6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n6f ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/CP46A_HUMAN CP46A_HUMAN]] Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Cholesterol 24-hydroxylase]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Gay S]] | [[Category: Gay, S C]] | ||
[[Category: Lane W]] | [[Category: Lane, W]] | ||
[[Category: Ch24h]] | |||
[[Category: Cyp46a1]] | |||
[[Category: Drug discovery]] | |||
[[Category: Oxidoreductase]] | |||
[[Category: Sbdd]] | |||
