3vv8: Difference between revisions

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<StructureSection load='3vv8' size='340' side='right'caption='[[3vv8]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='3vv8' size='340' side='right'caption='[[3vv8]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3vv8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VV8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3vv8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VV8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B02:2-AMINO-3-METHYL-6-[(1S,2R)-2-(3-METHYLBIPHENYL-4-YL)CYCLOPROPYL]PYRIMIDIN-4(3H)-ONE'>B02</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3vv6|3vv6]], [[3vv7|3vv7]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B02:2-AMINO-3-METHYL-6-[(1S,2R)-2-(3-METHYLBIPHENYL-4-YL)CYCLOPROPYL]PYRIMIDIN-4(3H)-ONE'>B02</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BACE1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vv8 OCA], [https://pdbe.org/3vv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vv8 RCSB], [https://www.ebi.ac.uk/pdbsum/3vv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vv8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vv8 OCA], [https://pdbe.org/3vv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vv8 RCSB], [https://www.ebi.ac.uk/pdbsum/3vv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vv8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Memapsin 2]]
[[Category: Arisawa M]]
[[Category: Arisawa, M]]
[[Category: Hattori K]]
[[Category: Hattori, K]]
[[Category: Higashino K]]
[[Category: Higashino, K]]
[[Category: Hosono M]]
[[Category: Hosono, M]]
[[Category: Muto C]]
[[Category: Muto, C]]
[[Category: Nakano T]]
[[Category: Nakano, T]]
[[Category: Sakagami M]]
[[Category: Sakagami, M]]
[[Category: Shuto S]]
[[Category: Shuto, S]]
[[Category: Takemoto H]]
[[Category: Takemoto, H]]
[[Category: Tanaka Y]]
[[Category: Tanaka, Y]]
[[Category: Togame H]]
[[Category: Togame, H]]
[[Category: Yamakawa H]]
[[Category: Yamakawa, H]]
[[Category: Yamamoto T]]
[[Category: Yamamoto, T]]
[[Category: Yonezawa S]]
[[Category: Yonezawa, S]]
[[Category: Aspartyl protease]]
[[Category: Base]]
[[Category: Beta-secretase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
Retrieved from "https://proteopedia.org/3vv8"