7y54: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 7y54 is ~~ON HOLD until Paper~~ Publication

==Crystal structure of sDscam Ig1 domain, isoform alpha1==

== Structural highlights ==

<table><tr><td colspan='2'>[[7y54]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chelicerata Chelicerata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y54 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y54 FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y54 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y54 OCA], [https://pdbe.org/7y54 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y54 RCSB], [https://www.ebi.ac.uk/pdbsum/7y54 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y54 ProSAT]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

To create a functional neural circuit, neurons develop a molecular identity to discriminate self from non-self. The invertebrate Dscam family and vertebrate Pcdh family are implicated in determining synaptic specificity. Recently identified in Chelicerata, a shortened Dscam (sDscam) has been shown to resemble the isoform-generating characters of both Dscam and Pcdh and represent an evolutionary transition. Here we presented the molecular details of sDscam self-recognition via both trans and cis interactions using X-ray crystallographic data and functional assays. Based on our results, we proposed a molecular zipper model for the assemblies of sDscam to mediate cell-cell recognition. In this model, sDscam utilized FNIII domain to form side-by-side interactions with neighboring molecules in the same cell while established hand-in-hand interactions via Ig1 domain with molecules from another cell around. Together, our study provided a framework for understanding the assembly, recognition, and evolution of sDscam.

~~Authors: Chen~~, Q., Yu, Y., ~~Cheng~~, J.

Structural basis for the self-recognition of sDSCAM in Chelicerata.,Cheng J, Yu Y, Wang X, Zheng X, Liu T, Hu D, Jin Y, Lai Y, Fu TM, Chen Q Nat Commun. 2023 May 2;14(1):2522. doi: 10.1038/s41467-023-38205-1. PMID:37130844<ref>PMID:37130844</ref>

~~Description~~: ~~Crystal structure of sDscam Ig1 domain, isoform alpha1~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

[[Category: ~~Unreleased Structures~~]]

</div>

[[Category: ~~Cheng, J~~]]

[[Category: Chen, Q]]

== References ==

[[Category: Yu, Y]]

__TOC__

</StructureSection>

[[Category: Chelicerata]]

[[Category: Large Structures]]

[[Category: Chen Q]]

[[Category: Cheng J]]

[[Category: Yu Y]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7y54 is ON HOLD  until Paper Publication
+==Crystal structure of sDscam Ig1 domain, isoform alpha1==
+<StructureSection load='7y54' size='340' side='right'caption='[[7y54]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7y54]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chelicerata Chelicerata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y54 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y54 FirstGlance]. <br>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y54 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y54 OCA], [https://pdbe.org/7y54 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y54 RCSB], [https://www.ebi.ac.uk/pdbsum/7y54 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y54 ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+To create a functional neural circuit, neurons develop a molecular identity to discriminate self from non-self. The invertebrate Dscam family and vertebrate Pcdh family are implicated in determining synaptic specificity. Recently identified in Chelicerata, a shortened Dscam (sDscam) has been shown to resemble the isoform-generating characters of both Dscam and Pcdh and represent an evolutionary transition. Here we presented the molecular details of sDscam self-recognition via both trans and cis interactions using X-ray crystallographic data and functional assays. Based on our results, we proposed a molecular zipper model for the assemblies of sDscam to mediate cell-cell recognition. In this model, sDscam utilized FNIII domain to form side-by-side interactions with neighboring molecules in the same cell while established hand-in-hand interactions via Ig1 domain with molecules from another cell around. Together, our study provided a framework for understanding the assembly, recognition, and evolution of sDscam.
-Authors: Chen, Q., Yu, Y., Cheng, J.
+Structural basis for the self-recognition of sDSCAM in Chelicerata.,Cheng J, Yu Y, Wang X, Zheng X, Liu T, Hu D, Jin Y, Lai Y, Fu TM, Chen Q Nat Commun. 2023 May 2;14(1):2522. doi: 10.1038/s41467-023-38205-1. PMID:37130844<ref>PMID:37130844</ref>
-Description: Crystal structure of sDscam Ig1 domain, isoform alpha1
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Cheng, J]]
+<div class="pdbe-citations 7y54" style="background-color:#fffaf0;"></div>
-[[Category: Chen, Q]]
+== References ==
-[[Category: Yu, Y]]
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Chelicerata]]
+[[Category: Large Structures]]
+[[Category: Chen Q]]
+[[Category: Cheng J]]
+[[Category: Yu Y]]