1htd: Difference between revisions

Line 1:

[[Image:1htd.~~gif~~|left|200px]]

[[Image:1htd.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~STRUCTURAL INTERACTION OF NATURAL AND SYNTHETIC INHIBITORS WITH THE VENOM METALLOPROTEINASE, ATROLYSIN C (HT-D)~~'''~~

===STRUCTURAL INTERACTION OF NATURAL AND SYNTHETIC INHIBITORS WITH THE VENOM METALLOPROTEINASE, ATROLYSIN C (HT-D)===

~~==Overview==~~

<!--

The ~~structure of~~ the ~~metalloproteinase and hemorrhagic toxin atrolysin C form d~~ (~~EC 3~~.4.~~24.42~~), ~~from the venom of~~ the ~~western diamondback rattlesnake Crotalus atrox, has been determined to atomic resolution by x-ray crystallographic methods~~. ~~This study illuminates the nature of inhibitor binding with natural (< Glu~~-~~Asn~~-Trp, where < Glu is pyroglutamic acid) and synthetic (SCH 47890) ligands. The primary specificity pocket is exceptionally deep; the nature of inhibitor and productive substrate binding is discussed. Insights gained from the study of these complexes facilitate the design of potential drugs to treat diseases where matrix metalloproteinases have been implicated, e.g., arthritis and tumor metastasis.

The line below this paragraph, {{ABSTRACT_PUBMED_8078901}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 8078901 is the PubMed ID number.

-->

==About this Structure==

Line 33:

Line 37:

[[Category: Zhang, D.]]

[[Category: Metalloprotease]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 19~~:12:40 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:39:04 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1htd.gif|left|200px]]
+{{Seed}}
+[[Image:1htd.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1htd|  PDB=1htd  |  SCENE=  }}
-'''STRUCTURAL INTERACTION OF NATURAL AND SYNTHETIC INHIBITORS WITH THE VENOM METALLOPROTEINASE, ATROLYSIN C (HT-D)'''
+===STRUCTURAL INTERACTION OF NATURAL AND SYNTHETIC INHIBITORS WITH THE VENOM METALLOPROTEINASE, ATROLYSIN C (HT-D)===
-==Overview==
+<!--
-The structure of the metalloproteinase and hemorrhagic toxin atrolysin C form d (EC 3.4.24.42), from the venom of the western diamondback rattlesnake Crotalus atrox, has been determined to atomic resolution by x-ray crystallographic methods. This study illuminates the nature of inhibitor binding with natural (&lt; Glu-Asn-Trp, where &lt; Glu is pyroglutamic acid) and synthetic (SCH 47890) ligands. The primary specificity pocket is exceptionally deep; the nature of inhibitor and productive substrate binding is discussed. Insights gained from the study of these complexes facilitate the design of potential drugs to treat diseases where matrix metalloproteinases have been implicated, e.g., arthritis and tumor metastasis.
+The line below this paragraph, {{ABSTRACT_PUBMED_8078901}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 8078901 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_8078901}}
 ==About this Structure==
@@ Line 33: / Line 37: @@
 [[Category: Zhang, D.]]
 [[Category: Metalloprotease]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 19:12:40 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 08:39:04 2008''