1fvt: Difference between revisions
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New page: left|200px<br /> <applet load="1fvt" size="450" color="white" frame="true" align="right" spinBox="true" caption="1fvt, resolution 2.2Å" /> '''THE STRUCTURE OF CYC... |
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[[Image:1fvt.gif|left|200px]]<br /> | [[Image:1fvt.gif|left|200px]]<br /><applet load="1fvt" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1fvt" size=" | |||
caption="1fvt, resolution 2.2Å" /> | caption="1fvt, resolution 2.2Å" /> | ||
'''THE STRUCTURE OF CYCLIN-DEPENDENT KINASE 2 (CDK2) IN COMPLEX WITH AN OXINDOLE INHIBITOR'''<br /> | '''THE STRUCTURE OF CYCLIN-DEPENDENT KINASE 2 (CDK2) IN COMPLEX WITH AN OXINDOLE INHIBITOR'''<br /> | ||
==Overview== | ==Overview== | ||
Most traditional cytotoxic anticancer agents ablate the rapidly dividing | Most traditional cytotoxic anticancer agents ablate the rapidly dividing epithelium of the hair follicle and induce alopecia (hair loss). Inhibition of cyclin-dependent kinase 2 (CDK2), a positive regulator of eukaryotic cell cycle progression, may represent a therapeutic strategy for prevention of chemotherapy-induced alopecia (CIA) by arresting the cell cycle and reducing the sensitivity of the epithelium to many cell cycle-active antitumor agents. Potent small-molecule inhibitors of CDK2 were developed using structure-based methods. Topical application of these compounds in a neonatal rat model of CIA reduced hair loss at the site of application in 33 to 50% of the animals. Thus, inhibition of CDK2 represents a potentially useful approach for the prevention of CIA in cancer patients. | ||
==About this Structure== | ==About this Structure== | ||
1FVT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with 106 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http:// | 1FVT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=106:'>106</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FVT OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Benson, B | [[Category: Benson, B G.]] | ||
[[Category: Bramson, H | [[Category: Bramson, H N.]] | ||
[[Category: Chapman, D | [[Category: Chapman, D E.]] | ||
[[Category: Davis, S | [[Category: Davis, S T.]] | ||
[[Category: Dickerson, S | [[Category: Dickerson, S H.]] | ||
[[Category: Dold, K | [[Category: Dold, K M.]] | ||
[[Category: Eberwein, D | [[Category: Eberwein, D J.]] | ||
[[Category: Edelstein, M.]] | [[Category: Edelstein, M.]] | ||
[[Category: Frye, S | [[Category: Frye, S V.]] | ||
[[Category: Griffin, R | [[Category: Griffin, R J.]] | ||
[[Category: Harris, P | [[Category: Harris, P A.]] | ||
[[Category: Hassell, A | [[Category: Hassell, A M.]] | ||
[[Category: Holmes, W | [[Category: Holmes, W D.]] | ||
[[Category: Hunter, R | [[Category: Hunter, R N.]] | ||
[[Category: Jr., R | [[Category: Jr., R T.Gampe.]] | ||
[[Category: Knick, V | [[Category: Knick, V B.]] | ||
[[Category: Kuyper, L | [[Category: Kuyper, L K.]] | ||
[[Category: Lackey, K.]] | [[Category: Lackey, K.]] | ||
[[Category: Lovejoy, B.]] | [[Category: Lovejoy, B.]] | ||
[[Category: Luzzio, M | [[Category: Luzzio, M J.]] | ||
[[Category: Murray, D.]] | [[Category: Murray, D.]] | ||
[[Category: Parker, P.]] | [[Category: Parker, P.]] | ||
[[Category: Rocque, W | [[Category: Rocque, W J.]] | ||
[[Category: Shewchuk, L.]] | [[Category: Shewchuk, L.]] | ||
[[Category: Veal, J | [[Category: Veal, J M.]] | ||
[[Category: Walker, D | [[Category: Walker, D H.]] | ||
[[Category: 106]] | [[Category: 106]] | ||
[[Category: cyclin-dependent kinase]] | [[Category: cyclin-dependent kinase]] | ||
[[Category: oxindole]] | [[Category: oxindole]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:43:10 2008'' | ||
