8ddz: Difference between revisions
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==TEM-1 beta-lactamase A237Y== | |||
<StructureSection load='8ddz' size='340' side='right'caption='[[8ddz]], [[Resolution|resolution]] 1.45Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8ddz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DDZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DDZ FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ddz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ddz OCA], [https://pdbe.org/8ddz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ddz RCSB], [https://www.ebi.ac.uk/pdbsum/8ddz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ddz ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/BLAT_ECOLX BLAT_ECOLX]] TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli]] | |||
[[Category: Large Structures]] | |||
[[Category: Boxer SG]] | |||
[[Category: Ji Z]] | |||
[[Category: Mathews II]] | |||
