1hty: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
Line 1: Line 1:
[[Image:1hty.gif|left|200px]]
{{Seed}}
[[Image:1hty.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1hty|  PDB=1hty  |  SCENE=  }}  
{{STRUCTURE_1hty|  PDB=1hty  |  SCENE=  }}  


'''GOLGI ALPHA-MANNOSIDASE II'''
===GOLGI ALPHA-MANNOSIDASE II===




==Overview==
<!--
Golgi alpha-mannosidase II, a key enzyme in N-glycan processing, is a target in the development of anti- cancer therapies. The crystal structure of Drosophila Golgi alpha-mannosidase II in the absence and presence of the anti-cancer agent swainsonine and the inhibitor deoxymannojirimycin reveals a novel protein fold with an active site zinc intricately involved both in the substrate specificity of the enzyme and directly in the catalytic mechanism. Identification of a putative GlcNAc binding pocket in the vicinity of the active site cavity provides a model for the binding of the GlcNAcMan(5)GlcNAc(2) substrate and the consecutive hydrolysis of the alpha1,6- and alpha1,3-linked mannose residues. The enzyme-inhibitor interactions observed provide insight into the catalytic mechanism, opening the door to the design of novel inhibitors of alpha-mannosidase II.
The line below this paragraph, {{ABSTRACT_PUBMED_11406577}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11406577 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_11406577}}


==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: N-terminal alpha-beta domain]]
[[Category: N-terminal alpha-beta domain]]
[[Category: Three helix bundle]]
[[Category: Three helix bundle]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:13:40 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:40:23 2008''

Revision as of 05:40, 1 July 2008

File:1hty.png

Template:STRUCTURE 1hty

GOLGI ALPHA-MANNOSIDASE II

Template:ABSTRACT PUBMED 11406577

About this Structure

1HTY is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells., van den Elsen JM, Kuntz DA, Rose DR, EMBO J. 2001 Jun 15;20(12):3008-17. PMID:11406577

Page seeded by OCA on Tue Jul 1 08:40:23 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1hty&oldid=608735"