1hu0: Difference between revisions

From Proteopedia
Jump to navigationJump to search
OCA (talk | contribs)
No edit summary
OCA (talk | contribs)
No edit summary
Line 1: Line 1:
[[Image:1hu0.gif|left|200px]]
{{Seed}}
[[Image:1hu0.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1hu0|  PDB=1hu0  |  SCENE=  }}  
{{STRUCTURE_1hu0|  PDB=1hu0  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF AN HOGG1-DNA BOROHYDRIDE TRAPPED INTERMEDIATE COMPLEX'''
===CRYSTAL STRUCTURE OF AN HOGG1-DNA BOROHYDRIDE TRAPPED INTERMEDIATE COMPLEX===




==Overview==
<!--  
Most spontaneous damage to bases in DNA is corrected through the action of the base-excision DNA repair pathway. Base excision repair is initiated by DNA glycosylases, lesion-specific enzymes that intercept aberrant bases in DNA and catalyze their excision. How such proteins accomplish the feat of catalyzing no fewer than five sequential reaction steps using a single active site has been unknown. To help answer this, we report the structure of a trapped catalytic intermediate in DNA repair by human 8-oxoguanine DNA glycosylase. This structure and supporting biochemical results reveal that the enzyme sequesters the excised lesion base and exploits it as a cofactor to participate in catalysis. To our knowledge, the present example represents the first documented case of product-assisted catalysis in an enzyme-catalyzed reaction.
The line below this paragraph, {{ABSTRACT_PUBMED_12592398}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12592398 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_12592398}}


==Disease==
==Disease==
Line 37: Line 41:
[[Category: Protein/dna]]
[[Category: Protein/dna]]
[[Category: Reaction intermediate]]
[[Category: Reaction intermediate]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:13:50 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:40:31 2008''

Revision as of 05:40, 1 July 2008

File:1hu0.png

Template:STRUCTURE 1hu0

CRYSTAL STRUCTURE OF AN HOGG1-DNA BOROHYDRIDE TRAPPED INTERMEDIATE COMPLEX

Template:ABSTRACT PUBMED 12592398

Disease

Known disease associated with this structure: Renal cell carcinoma, clear cell, somatic OMIM:[601982]

About this Structure

1HU0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Product-assisted catalysis in base-excision DNA repair., Fromme JC, Bruner SD, Yang W, Karplus M, Verdine GL, Nat Struct Biol. 2003 Mar;10(3):204-11. PMID:12592398

Page seeded by OCA on Tue Jul 1 08:40:31 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA