3w9p: Difference between revisions
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<StructureSection load='3w9p' size='340' side='right'caption='[[3w9p]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='3w9p' size='340' side='right'caption='[[3w9p]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3w9p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3w9p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Actinia_fragacea Actinia fragacea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W9P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W9P FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w9p OCA], [https://pdbe.org/3w9p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w9p RCSB], [https://www.ebi.ac.uk/pdbsum/3w9p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w9p ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w9p OCA], [https://pdbe.org/3w9p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w9p RCSB], [https://www.ebi.ac.uk/pdbsum/3w9p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w9p ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/ACTPC_ACTFR ACTPC_ACTFR] Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cardiac stimulation and hemolysis. Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of several monomers.<ref>PMID:19563820</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Actinia fragacea]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Caaveiro | [[Category: Caaveiro JMM]] | ||
[[Category: Tanaka | [[Category: Tanaka K]] | ||
[[Category: Tsumoto | [[Category: Tsumoto K]] | ||
