3wqb: Difference between revisions
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<StructureSection load='3wqb' size='340' side='right'caption='[[3wqb]], [[Resolution|resolution]] 1.41Å' scene=''> | <StructureSection load='3wqb' size='340' side='right'caption='[[3wqb]], [[Resolution|resolution]] 1.41Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3wqb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3wqb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aeromonas_sobria Aeromonas sobria]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WQB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WQB FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.41Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wqb OCA], [https://pdbe.org/3wqb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wqb RCSB], [https://www.ebi.ac.uk/pdbsum/3wqb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wqb ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wqb OCA], [https://pdbe.org/3wqb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wqb RCSB], [https://www.ebi.ac.uk/pdbsum/3wqb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wqb ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/ASP_AERSO ASP_AERSO] Exhibits serine protease activity (PubMed:11092244, PubMed:12153115, PubMed:16487335, PubMed:18067862, PubMed:18462393, PubMed:19654332). Preferentially cleaves the peptide bond following two basic residues, one of which is Lys, but does not recognize the bond following a single basic residue (PubMed:16487335). Probable potent virulence factor that cleaves various host plasma proteins, including prekallikrein, prothrombin and fibrinogen (PubMed:16487335, PubMed:17142774, PubMed:18067862, PubMed:18462393, PubMed:19654332). ASP induces vascular leakage and reduction in blood pressure by activating the host plasma kallikrein/kinin system (PubMed:12153115, PubMed:16487335, PubMed:17142774). It affects the host coagulation system during infection through activation of prothrombin to alpha-thrombin and degradation of fibrinogen, which impairs plasma clottability (PubMed:18067862, PubMed:18462393). It also hydrolyzes the complement component C5, releasing the C5a anaphylatoxin, which causes the formation of pus and edema (PubMed:18714034). In addition, degrades its external chaperone ORF2 after the secretion of the ASP-ORF2 complex (PubMed:25784551).<ref>PMID:11092244</ref> <ref>PMID:12153115</ref> <ref>PMID:16487335</ref> <ref>PMID:17142774</ref> <ref>PMID:18067862</ref> <ref>PMID:18462393</ref> <ref>PMID:18714034</ref> <ref>PMID:19654332</ref> <ref>PMID:25784551</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Aeromonas sobria]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Kato | [[Category: Kato R]] | ||
[[Category: Kobayashi | [[Category: Kobayashi H]] | ||
[[Category: Miyakawa | [[Category: Miyakawa T]] | ||
[[Category: Tanokura | [[Category: Tanokura M]] | ||
[[Category: Tashiro | [[Category: Tashiro M]] | ||
[[Category: Tsuge | [[Category: Tsuge H]] | ||
[[Category: Yamanaka | [[Category: Yamanaka H]] | ||
[[Category: Yoshida | [[Category: Yoshida T]] | ||
